Slaying the “Troll of Transplantation”—new frontiers in cytomegalovirus management: A report from the CMV International Symposium 2023

Camille N. Kotton*, Julian Torre-Cisneros, Ibrahim Yakoub-Agha, Sophie Alain, Reem Al-Maghrabi, David Beauvais, Oriol Bestard, Udo Boeken, Emily Blumberg, Roy Chemaly, Lana Desnica, Mario Fernández-Ruiz, Raffaella Greco, Paolo Grossi, Nassim Kamar, Hannah Kaminski, Nikolaus Kneidinger, Guido Kobbe, Michele Malagola, María E. Martínez-MuñozLigia Pierrotti, Luciano Potena, Antoine Roux, Karthik Santhanakrishnan, Martina Sester, Osnat Shtraichman, Marty Zamora, Andreas Zuckermann

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

The 2023 International CMV Symposium took place in Barcelona in May 2023. During the 2-day meeting, delegates and faculty discussed the ongoing challenge of managing the risk of cytomegalovirus infection (the Troll of Transplantation) after solid organ or hematopoietic cell transplantation. Opportunities to improve outcomes of transplant recipients by applying advances in antiviral prophylaxis or pre-emptive therapy, immunotherapy, and monitoring of cell-mediated immunity to routine clinical practice were debated and relevant educational clinical cases presented. This review summarizes the presentations, cases, and discussions from the meeting and describes how further advances are needed before the Troll of Transplantation is slain. (Figure presented.).

Original languageEnglish
Article numbere14183
JournalTransplant Infectious Disease
Volume26
Issue number1
DOIs
StatePublished - Feb 2024
Externally publishedYes

Funding

FundersFunder number
Biotest AG
Camille Kotton
Consorcio Centro de Investigación Biomédica en RedCB 2021
Elements Communications Ltd
Ibrahim Yakoub-Agha
Ministerio de Ciencia e Innovación and Unión Europea
Roche
Center for International Business Education and Research, University of Illinois at Urbana-Champaign
Meso Scale Diagnostics
Instituto de Salud Carlos III

    Keywords

    • CMV immunoglobulin
    • cell-mediated immunity
    • hematopoietic cell transplant
    • resistance
    • solid organ transplant
    • vaccines

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