Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015)

Jatin P. Shah; Helena Levyn; Cristina Valero; Dauren Adilbay; Alana Eagan; Junting Zheng; Mithat Gonen; Marc Cohen; Snehal Patel; Ian Ganly; Prathamesh Pai; Paolo Castelnuovo; Fang Ju Gao; Cesare Piazza; Piero Nicolai; Ben Panizza; James Bowman; Catherine Barnett; Luiz P. Kowalski; Ronaldo Toledo; Dan M. Fliss; John DeAlmeida; Ian Witterick; Philippe Herman; Walter Fontanella; Gregorio Sanchez Aniceto; Sefik Hosal; Serdar Ozer; Subramania Iyer; Richard Harvey; C. Rene Leemans; Jan Jaap Hendrickx; Marcelo Figari; Luis Boccalatte; Ken Ichi Nibu; Peter Clarke; Catherine Rennie; Zhu Yi Ming; Claudio Cernea; Sergio Goncalves; Rodney Schlosser; Fernando Dias; Zoukaa Sargi; Shahzada Ahmed; Wojciech Golusinski; Se Heon Kim; Shirley Y. Su; Shaan M. Raza; Franco DeMonte; Ehab Hanna

doi:10.1002/hed.27746

Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015)

Jatin P. Shah^*, Helena Levyn, Cristina Valero, Dauren Adilbay, Alana Eagan, Junting Zheng, Mithat Gonen, Marc Cohen, Snehal Patel, Ian Ganly, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Ben Panizza, James Bowman, Catherine Barnett, Luiz P. Kowalski, Ronaldo ToledoDan M. Fliss, John DeAlmeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard Harvey, C. Rene Leemans, Jan Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken Ichi Nibu, Peter Clarke, Catherine Rennie, Zhu Yi Ming, Claudio Cernea, Sergio Goncalves, Rodney Schlosser, Fernando Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide. Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes. Results: The median age was 56 years (IQR 44–67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor. Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

Original language	English
Pages (from-to)	2762-2775
Number of pages	14
Journal	Head and Neck
Volume	46
Issue number	11
DOIs	https://doi.org/10.1002/hed.27746
State	Published - Nov 2024
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health
National Cancer Institute	P30 CA008748

Keywords

global collaboration
multimodality treatment
prognostic factors
skull base tumors
survival outcomes

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10.1002/hed.27746

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Shah, J. P., Levyn, H., Valero, C., Adilbay, D., Eagan, A., Zheng, J., Gonen, M., Cohen, M., Patel, S., Ganly, I., Pai, P., Castelnuovo, P., Gao, F. J., Piazza, C., Nicolai, P., Panizza, B., Bowman, J., Barnett, C., Kowalski, L. P., ... Hanna, E. (2024). Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015). Head and Neck, 46(11), 2762-2775. https://doi.org/10.1002/hed.27746

@article{640909ed01314d8b9a1386ce0a5d6fd3,

title = "Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015)",

abstract = "Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide. Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes. Results: The median age was 56 years (IQR 44–67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor. Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.",

keywords = "global collaboration, multimodality treatment, prognostic factors, skull base tumors, survival outcomes",

author = "Shah, {Jatin P.} and Helena Levyn and Cristina Valero and Dauren Adilbay and Alana Eagan and Junting Zheng and Mithat Gonen and Marc Cohen and Snehal Patel and Ian Ganly and Prathamesh Pai and Paolo Castelnuovo and Gao, {Fang Ju} and Cesare Piazza and Piero Nicolai and Ben Panizza and James Bowman and Catherine Barnett and Kowalski, {Luiz P.} and Ronaldo Toledo and Fliss, {Dan M.} and John DeAlmeida and Ian Witterick and Philippe Herman and Walter Fontanella and Aniceto, {Gregorio Sanchez} and Sefik Hosal and Serdar Ozer and Subramania Iyer and Richard Harvey and Leemans, {C. Rene} and Hendrickx, {Jan Jaap} and Marcelo Figari and Luis Boccalatte and Nibu, {Ken Ichi} and Peter Clarke and Catherine Rennie and Ming, {Zhu Yi} and Claudio Cernea and Sergio Goncalves and Rodney Schlosser and Fernando Dias and Zoukaa Sargi and Shahzada Ahmed and Wojciech Golusinski and Kim, {Se Heon} and Su, {Shirley Y.} and Raza, {Shaan M.} and Franco DeMonte and Ehab Hanna",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley Periodicals LLC.",

year = "2024",

month = nov,

doi = "10.1002/hed.27746",

language = "אנגלית",

volume = "46",

pages = "2762--2775",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

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Shah, JP, Levyn, H, Valero, C, Adilbay, D, Eagan, A, Zheng, J, Gonen, M, Cohen, M, Patel, S, Ganly, I, Pai, P, Castelnuovo, P, Gao, FJ, Piazza, C, Nicolai, P, Panizza, B, Bowman, J, Barnett, C, Kowalski, LP, Toledo, R, Fliss, DM, DeAlmeida, J, Witterick, I, Herman, P, Fontanella, W, Aniceto, GS, Hosal, S, Ozer, S, Iyer, S, Harvey, R, Leemans, CR, Hendrickx, JJ, Figari, M, Boccalatte, L, Nibu, KI, Clarke, P, Rennie, C, Ming, ZY, Cernea, C, Goncalves, S, Schlosser, R, Dias, F, Sargi, Z, Ahmed, S, Golusinski, W, Kim, SH, Su, SY, Raza, SM, DeMonte, F & Hanna, E 2024, 'Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015)', Head and Neck, vol. 46, no. 11, pp. 2762-2775. https://doi.org/10.1002/hed.27746

TY - JOUR

T1 - Skull base surgery for malignant tumors

T2 - The 2nd international collaborative study (1995–2015)

AU - Shah, Jatin P.

AU - Levyn, Helena

AU - Valero, Cristina

AU - Adilbay, Dauren

AU - Eagan, Alana

AU - Zheng, Junting

AU - Gonen, Mithat

AU - Cohen, Marc

AU - Patel, Snehal

AU - Ganly, Ian

AU - Pai, Prathamesh

AU - Castelnuovo, Paolo

AU - Gao, Fang Ju

AU - Piazza, Cesare

AU - Nicolai, Piero

AU - Panizza, Ben

AU - Bowman, James

AU - Barnett, Catherine

AU - Kowalski, Luiz P.

AU - Toledo, Ronaldo

AU - Fliss, Dan M.

AU - DeAlmeida, John

AU - Witterick, Ian

AU - Herman, Philippe

AU - Fontanella, Walter

AU - Aniceto, Gregorio Sanchez

AU - Hosal, Sefik

AU - Ozer, Serdar

AU - Iyer, Subramania

AU - Harvey, Richard

AU - Leemans, C. Rene

AU - Hendrickx, Jan Jaap

AU - Figari, Marcelo

AU - Boccalatte, Luis

AU - Nibu, Ken Ichi

AU - Clarke, Peter

AU - Rennie, Catherine

AU - Ming, Zhu Yi

AU - Cernea, Claudio

AU - Goncalves, Sergio

AU - Schlosser, Rodney

AU - Dias, Fernando

AU - Sargi, Zoukaa

AU - Ahmed, Shahzada

AU - Golusinski, Wojciech

AU - Kim, Se Heon

AU - Su, Shirley Y.

AU - Raza, Shaan M.

AU - DeMonte, Franco

AU - Hanna, Ehab

PY - 2024/11

Y1 - 2024/11

N2 - Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide. Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes. Results: The median age was 56 years (IQR 44–67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor. Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

AB - Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide. Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes. Results: The median age was 56 years (IQR 44–67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor. Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

KW - global collaboration

KW - multimodality treatment

KW - prognostic factors

KW - skull base tumors

KW - survival outcomes

UR - http://www.scopus.com/inward/record.url?scp=85193698963&partnerID=8YFLogxK

U2 - 10.1002/hed.27746

DO - 10.1002/hed.27746

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 38770972

AN - SCOPUS:85193698963

SN - 1043-3074

VL - 46

SP - 2762

EP - 2775

JO - Head and Neck

JF - Head and Neck

IS - 11

ER -

Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015)

Abstract

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Keywords

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