@article{90ae748dddda4e5c986b022e3cdf1ab1,
title = "Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior",
abstract = "Ultraviolet (UV) light affects endocrinological and behavioral aspects of sexuality via an unknown mechanism. Here we discover that ultraviolet B (UVB) exposure enhances the levels of sex-steroid hormones and sexual behavior, which are mediated by the skin. In female mice, UVB exposure increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in larger ovaries; extends estrus days; and increases anti-Mullerian hormone (AMH) expression. UVB exposure also enhances the sexual responsiveness and attractiveness of females and male-female interactions. Conditional knockout of p53 specifically in skin keratinocytes abolishes the effects of UVB. Thus, UVB triggers a skin-brain-gonadal axis through skin p53 activation. In humans, solar exposure enhances romantic passion in both genders and aggressiveness in men, as seen in analysis of individual questionaries, and positively correlates with testosterone level. Our findings suggest opportunities for treatment of sex-steroid-related dysfunctions.",
keywords = "HPG axis, UVB, behavioral, hormones, p53, questionnaires, sexuality, skin, solar, testosterone",
author = "Roma Parikh and Eschar Sorek and Shivang Parikh and Keren Michael and Lior Bikovski and Sagi Tshori and Galit Shefer and Shira Mingelgreen and Taiba Zornitzki and Hilla Knobler and Gabriel Chodick and Mariya Mardamshina and Arjan Boonman and Noga Kronfeld-Schor and Hadas Bar-Joseph and Dalit Ben-Yosef and Hadar Amir and Mor Pavlovsky and Hagit Matz and Tom Ben-Dov and Tamar Golan and Eran Nizri and Daphna Liber and Yair Liel and Ronen Brenner and Yftach Gepner and Orit Karnieli-Miller and Rina Hemi and Ruth Shalgi and Tali Kimchi and Ruth Percik and Aron Weller and Carmit Levy",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = aug,
day = "24",
doi = "10.1016/j.celrep.2021.109579",
language = "אנגלית",
volume = "36",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "8",
}