Sjögren's syndrome, the old and the new

Yogev Peri, Nancy Agmon-Levin, Emanuel Theodor, Yehuda Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Sjögren's syndrome is a chronic autoimmune disease characterised by progressive injury to exocrine glands accompanied by diverse extra-glandular manifestations. The spectrum of Sjögren's manifestations expanded in recent years to include new symptoms and signs such as small fibre neuropathy, and also well-defined activity and prognostic indexes. Similar to other non-organ-specific autoimmune diseases, a mosaic of factors have been linked with the development and appearances of Sjögren's syndrome. Progress has been made unravelling those factors, including susceptibility genes, immunological parameters and various environmental factors in the last decade, some of which may enable targeted therapies, biological and non-biological ones, for patients suffering from this disease. Thus, herein we review the postulated aetiologies, pathogenesis and new insights related to Sjögren's syndrome.

Original languageEnglish
Pages (from-to)105-117
Number of pages13
JournalBest Practice and Research: Clinical Rheumatology
Issue number1
StatePublished - Feb 2012


  • Autoantibodies
  • Autoimmunity
  • Biological therapies
  • Neuropathy
  • Sjögren's syndrome


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