TY - JOUR
T1 - Sjögren's syndrome, the old and the new
AU - Peri, Yogev
AU - Agmon-Levin, Nancy
AU - Theodor, Emanuel
AU - Shoenfeld, Yehuda
PY - 2012/2
Y1 - 2012/2
N2 - Sjögren's syndrome is a chronic autoimmune disease characterised by progressive injury to exocrine glands accompanied by diverse extra-glandular manifestations. The spectrum of Sjögren's manifestations expanded in recent years to include new symptoms and signs such as small fibre neuropathy, and also well-defined activity and prognostic indexes. Similar to other non-organ-specific autoimmune diseases, a mosaic of factors have been linked with the development and appearances of Sjögren's syndrome. Progress has been made unravelling those factors, including susceptibility genes, immunological parameters and various environmental factors in the last decade, some of which may enable targeted therapies, biological and non-biological ones, for patients suffering from this disease. Thus, herein we review the postulated aetiologies, pathogenesis and new insights related to Sjögren's syndrome.
AB - Sjögren's syndrome is a chronic autoimmune disease characterised by progressive injury to exocrine glands accompanied by diverse extra-glandular manifestations. The spectrum of Sjögren's manifestations expanded in recent years to include new symptoms and signs such as small fibre neuropathy, and also well-defined activity and prognostic indexes. Similar to other non-organ-specific autoimmune diseases, a mosaic of factors have been linked with the development and appearances of Sjögren's syndrome. Progress has been made unravelling those factors, including susceptibility genes, immunological parameters and various environmental factors in the last decade, some of which may enable targeted therapies, biological and non-biological ones, for patients suffering from this disease. Thus, herein we review the postulated aetiologies, pathogenesis and new insights related to Sjögren's syndrome.
KW - Autoantibodies
KW - Autoimmunity
KW - Biological therapies
KW - Neuropathy
KW - Sjögren's syndrome
UR - http://www.scopus.com/inward/record.url?scp=84858377907&partnerID=8YFLogxK
U2 - 10.1016/j.berh.2012.01.012
DO - 10.1016/j.berh.2012.01.012
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AN - SCOPUS:84858377907
SN - 1521-6942
VL - 26
SP - 105
EP - 117
JO - Best Practice and Research: Clinical Rheumatology
JF - Best Practice and Research: Clinical Rheumatology
IS - 1
ER -