We evaluated the state of leukocyte adhesiveness/aggregation in the peripheral blood of 33 patients with stress and 33 patients with infection/inflammation. Both groups had a similar white blood cell count (9542 ±3067 and 10,512 ±2758 cells per cmm, respectively). It was found that the percentage of aggregated leukocytes in the peripheral blood of patients with infection/inflammation was significantly higher than in the patients with stress (24.7 ±11 per cent versus 15.8 ±6 per cent; p < 0.0001). When we analyzed the size distribution of the aggregated cells we also found a significant difference between the number of couplets (2.7 ±1.9 versus 1.6 + 0.9; p = 0.006), triplets (0.6+1.3 versus 0.2 ±0.2; p = 0.05), quadruplets (0.14 ±0.2 versus 0.03 ±0.07; p = 0.005) or quintets (0.04 ±0.1 versus 0.003 ±0.002; p = 0.05) between these two groups. Thus, by using a simple slide test to reveal the state of leukocyte adhesiveness/aggregation in the peripheral blood one could favor the diagnosis of infection/inflammation induced leukocytosis as opposed to a stress-related one.
|Number of pages||7|
|State||Published - Mar 2000|
- Leukocyte adhesiveness/aggregation