TY - JOUR
T1 - Site‐directed chemotherapy with a drug bound to anti‐idiotypic antibody to a lymphoma cell‐surface IgM
AU - Hurwitz, Esther
AU - Kashi, Rina
AU - Burowsky, Daphna
AU - Arnon, Ruth
AU - Haimovich, Joseph
PY - 1983/6/15
Y1 - 1983/6/15
N2 - Xenogeneic antibodies against the cell‐surface IgM of a B‐cell lymphoma (38C‐13) were coupled through a dextran bridge to the anti‐neoplastic drug, daunomycin. The conjugate maintained both its antibody and its drug activity. The effectiveness of the conjugate was tested in vivo in mice challenged with the 38C‐13 lymphoma. Drug conjugates of the idiotypic antibodies injected intraperitoneally 2 days after tumor transplantation almost completely inhibited tumor development. The controls, daunomycin‐dextran‐goat anti‐DNP, free daunomycin, or the antibodies alone had no effect or only delayed the tumor development.
AB - Xenogeneic antibodies against the cell‐surface IgM of a B‐cell lymphoma (38C‐13) were coupled through a dextran bridge to the anti‐neoplastic drug, daunomycin. The conjugate maintained both its antibody and its drug activity. The effectiveness of the conjugate was tested in vivo in mice challenged with the 38C‐13 lymphoma. Drug conjugates of the idiotypic antibodies injected intraperitoneally 2 days after tumor transplantation almost completely inhibited tumor development. The controls, daunomycin‐dextran‐goat anti‐DNP, free daunomycin, or the antibodies alone had no effect or only delayed the tumor development.
UR - http://www.scopus.com/inward/record.url?scp=0020595398&partnerID=8YFLogxK
U2 - 10.1002/ijc.2910310612
DO - 10.1002/ijc.2910310612
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C2 - 6862683
AN - SCOPUS:0020595398
SN - 0020-7136
VL - 31
SP - 745
EP - 748
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 6
ER -
