TY - JOUR
T1 - Sinus rhythm restoration after atrial fibrillation
T2 - The clinical value of N-Terminal pro-BNP measurements
AU - Danicek, Vladimir
AU - Theodorovich, Nick
AU - Bar-Chaim, Shmuel
AU - Miller, Asaf
AU - Vered, Zvi
AU - Koren-Morag, Nira
AU - Uriel, Nir
AU - Czuriga, Istvan
AU - Shopen, Andrey
AU - Brantriss, Nurit
AU - Kaluski, Edo
PY - 2008/8
Y1 - 2008/8
N2 - Aim: To examine the effects of sinus rhythm (SR) restoration on N-Terminal pro-BNP (NTP-BNP) in patients with atrial fibrillation (AF). Methods: Subjects with paroxysmal and persistent AF and absence of organic heart disease were prospectively studied. Chemical or electrical restoration of SR was attempted within 48 hours (n = 37) or >3 weeks (n = 73). Clinical and laboratory (NTP-BNP, 72-hour Holter monitor, and electrocardiogram) assessment were obtained at baseline and at 1, 30, and 180 days after SR restoration. Patients were divided into three predefined "outcome groups": (a) maintenance of SR for 1 month, (b) SR with recurrent paroxysmal AF (PaAF), and (c) early (<30 days) recurrence persistent AF (RAF). Results: Of the 110 patients enrolled, 89 had initial successful SR restoration. Baseline NTP-BNP was 936 pg/mL (interquartile range (IQR) 333-2,026); ratio between baseline and 30-day NTP-BNP was 10.2 (IQR 6.42-22.0) for SR group, 3.3 (IQR 2.45-7.34) for PaAF, and 1.07 (IQR 0.87-1.22) for RAF (P < 0.001). Patients with ratio ≤3 were more likely to have PaAF (46% vs 3%, OR 30, P < 0.001). Conclusion: With SR restoration, NTP-BNP decline is observed up to 1 month. NTP-BNP drop is partially or completely abolished by PaAF and RAF, respectively. NTP-BNP does not predict successful SR restoration.
AB - Aim: To examine the effects of sinus rhythm (SR) restoration on N-Terminal pro-BNP (NTP-BNP) in patients with atrial fibrillation (AF). Methods: Subjects with paroxysmal and persistent AF and absence of organic heart disease were prospectively studied. Chemical or electrical restoration of SR was attempted within 48 hours (n = 37) or >3 weeks (n = 73). Clinical and laboratory (NTP-BNP, 72-hour Holter monitor, and electrocardiogram) assessment were obtained at baseline and at 1, 30, and 180 days after SR restoration. Patients were divided into three predefined "outcome groups": (a) maintenance of SR for 1 month, (b) SR with recurrent paroxysmal AF (PaAF), and (c) early (<30 days) recurrence persistent AF (RAF). Results: Of the 110 patients enrolled, 89 had initial successful SR restoration. Baseline NTP-BNP was 936 pg/mL (interquartile range (IQR) 333-2,026); ratio between baseline and 30-day NTP-BNP was 10.2 (IQR 6.42-22.0) for SR group, 3.3 (IQR 2.45-7.34) for PaAF, and 1.07 (IQR 0.87-1.22) for RAF (P < 0.001). Patients with ratio ≤3 were more likely to have PaAF (46% vs 3%, OR 30, P < 0.001). Conclusion: With SR restoration, NTP-BNP decline is observed up to 1 month. NTP-BNP drop is partially or completely abolished by PaAF and RAF, respectively. NTP-BNP does not predict successful SR restoration.
KW - Atrial fibrillation
KW - Cardioversion
KW - Heart failure
KW - Left atrium
KW - Pro-BNP
KW - Sinus rhythm
UR - http://www.scopus.com/inward/record.url?scp=48249115989&partnerID=8YFLogxK
U2 - 10.1111/j.1540-8159.2008.01121.x
DO - 10.1111/j.1540-8159.2008.01121.x
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AN - SCOPUS:48249115989
VL - 31
SP - 955
EP - 960
JO - PACE - Pacing and Clinical Electrophysiology
JF - PACE - Pacing and Clinical Electrophysiology
SN - 0147-8389
IS - 8
ER -