Single-triggered trimeric prodrugs

Keren Haba; Mikhail Popkov; Marina Shamis; Richard A. Lerner; Carlos F. Barbas; Doron Shabat

doi:10.1002/anie.200461657

Single-triggered trimeric prodrugs

Keren Haba, Mikhail Popkov, Marina Shamis, Richard A. Lerner, Carlos F. Barbas, Doron Shabat^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.

Original language	English
Pages (from-to)	716-720
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	5
DOIs	https://doi.org/10.1002/anie.200461657
State	Published - 21 Jan 2005

Keywords

Aldol reaction
Catalytic antibodies
Dendrimers
Drug delivery
Prodrugs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200461657

Cite this

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title = "Single-triggered trimeric prodrugs",

abstract = "The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.",

keywords = "Aldol reaction, Catalytic antibodies, Dendrimers, Drug delivery, Prodrugs",

author = "Keren Haba and Mikhail Popkov and Marina Shamis and Lerner, {Richard A.} and Barbas, {Carlos F.} and Doron Shabat",

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AU - Haba, Keren

AU - Popkov, Mikhail

AU - Shamis, Marina

AU - Lerner, Richard A.

AU - Barbas, Carlos F.

AU - Shabat, Doron

PY - 2005/1/21

Y1 - 2005/1/21

N2 - The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.

AB - The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.

KW - Aldol reaction

KW - Catalytic antibodies

KW - Dendrimers

KW - Drug delivery

KW - Prodrugs

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DO - 10.1002/anie.200461657

M3 - מאמר

AN - SCOPUS:13444274757

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EP - 720

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 5

ER -

Single-triggered trimeric prodrugs

Abstract

Keywords

UN SDGs

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