Single-triggered trimeric prodrugs

Keren Haba, Mikhail Popkov, Marina Shamis, Richard A. Lerner, Carlos F. Barbas, Doron Shabat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.

Original languageEnglish
Pages (from-to)716-720
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number5
StatePublished - 21 Jan 2005


  • Aldol reaction
  • Catalytic antibodies
  • Dendrimers
  • Drug delivery
  • Prodrugs


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