TY - JOUR
T1 - Single-Particle Cryo-Electron Microscopy
T2 - Mathematical Theory, Computational Challenges, and Opportunities
AU - Bendory, Tamir
AU - Bartesaghi, Alberto
AU - Singer, Amit
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/3
Y1 - 2020/3
N2 - In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize in Chemistry 2017 was awarded to three pioneers in the cryo-EM field: Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution" [93].
AB - In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize in Chemistry 2017 was awarded to three pioneers in the cryo-EM field: Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution" [93].
UR - http://www.scopus.com/inward/record.url?scp=85080959338&partnerID=8YFLogxK
U2 - 10.1109/MSP.2019.2957822
DO - 10.1109/MSP.2019.2957822
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AN - SCOPUS:85080959338
SN - 1053-5888
VL - 37
SP - 58
EP - 76
JO - IEEE Signal Processing Magazine
JF - IEEE Signal Processing Magazine
IS - 2
M1 - 9016106
ER -