Silicone Breast Implants and Autoimmune/Inflammatory Syndrome induced by Adjuvants (ASIA): A Literature Search

Elisabetta Borella, Eitan Israeli, Yehuda Shoenfeld

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Summary: Siliconosis is an autoimmune reaction induced by exposure to silicone. It was first described in the 1980s and has recently been included in autoimmune/inflammatory syndrome induced by adjuvants (ASIA). In this brief report, we aim to show data demonstrating that exposure to silicone elicits rheumatic symptoms and leads to ASIA in genetically predisposed individuals. For this purpose, we review the epidemiologic literature regarding an association between silicone breast implants and rheumatic symptoms, with particular emphasis on results drawn from the most recent investigations, many of which are large cohort studies with long-term follow-up. The epidemiological studies that we investigate show clinical reactions after silicone exposure, leading to ASIA in predisposed individuals. Genetic background seems to play an important role in development of the disease, according to animal and clinical studies. Our conclusion is that silicone triggers immune system activation and thus acts as an immune adjuvant. Its exposure may elicit the development of ASIA.

Original languageEnglish
Title of host publicationVaccines and Autoimmunity
PublisherWiley-Blackwell
Pages87-92
Number of pages6
ISBN (Electronic)9781118663721
ISBN (Print)9781118663431
DOIs
StatePublished - 1 Jan 2014

Keywords

  • ASIA
  • Autoimmunity
  • Connective tissue disease
  • Fatigue
  • Siliconosis
  • Systemic sclerosis

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