Sil overexpression in lung cancer characterizes tumors with increased mitotic activity

Ayelet Erez, Marina Perelman, Stephen M. Hewitt, Gadi Cojacaru, Iris Goldberg, Iris Shahar, Pnina Yaron, Inna Muler, Stefano Campaner, Ninette Amariglio, Gideon Rechavi, Ilan R. Kirsch, Meir Krupsky, Naftali Kaminski, Shai Izraeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Sil (SCL interrupting locus) was cloned from the most common chromosomal rearrangement in T-cell acute lymphoblastic leukemia. It is an immediate early gene whose expression is associated with cell proliferation. Sil protein levels are tightly regulated during the cell cycle, reaching peak levels in mitosis and disappearing on transition to G1. A recent study found Sil to be one of 17 genes whose overexpression in primary adenocarcinomas predicts metastatic spread. We hypothesized that Sil might have a role in carcinogenesis. To address this question, we utilized several approaches. Using a multitumor tissue array, we found that Sil protein expression was increased mostly in lung cancer, but also at lower levels, in a subset of other tumors. Microarray gene expression analysis and immunohistochemistry of lung cancer samples verified these observations. Sil gene expression in lung cancer correlated with the expression of several kinetochore check-point genes and with the histopathologic mitotic index. These observations suggest that overexpression of the Sil gene characterizes tumors with increased mitotic activity.

Original languageEnglish
Pages (from-to)5371-5377
Number of pages7
Issue number31
StatePublished - 8 Jul 2004


  • Carcinogenesis
  • Lung cancer
  • Mitosis
  • Sil


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