Significant increase in serum hCG levels following methotrexate therapy is associated with lower treatment success rates in ectopic pregnancy patients

Roy Mashiach, Inbar Kislev, Daniella Gilboa, Shali Mazaki-Tovi, Daniel S. Seidman, Mordechai Goldenberg, Jerome Bouaziz

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine the association between early increase in the serum hCG levels (days 0–4) and treatment success rates following methotrexate therapy in ectopic pregnancy patients. Study design: A level II-2 case-control study of involving 140 patients treated with methotrexate for ectopic pregnancy at the gynecology department in a tertiary care hospital. Results: A logistic regression model for the “failure of treatment” was fitted with serum hCG levels change between day 0 and day 4, patient age, pregnancy age at day-0, and day-0 β-hCG level as predictors. The logistic regression analysis indicated that having more than 50% increase in the β-hCG levels between days 0 and 4 significantly (P = 0.011) increases the risk of MTX treatment failure. Conclusion: The results of this study indicate that >50% increase in β-hCG levels between days 0 and 4 significantly increases the risk of methotrexate treatment failure. This novel information could assist patients and physicians in making decisions regarding ectopic pregnancy treatment.

Original languageEnglish
Pages (from-to)188-191
Number of pages4
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Volume231
DOIs
StatePublished - Dec 2018

Keywords

  • Ectopic pregnancy
  • Human chorionic gonadotropin
  • Methotrexate treatment success

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