TY - JOUR
T1 - Significance of elevated levels of serum creatine phosphokinase in febrile diseases
T2 - A prospective study
AU - Cohen, O.
AU - Leibovici, L.
AU - Mor, F.
AU - Wysenbeek, A. J.
PY - 1991
Y1 - 1991
N2 - The incidence and significance of elevated serum levels of creatine phosphokinase (CPK) in febrile diseases were studied prospectively in all patients admitted with fever to a department of medicine during 1 year. High serum CPK levels were detected in 70 (28%) of 247 febrile patients but in only six (6%) of 105 afebrile control patients (P = .0001). Elevated CPK levels were not related to any specific diagnosis. Logistic regression analysis identified five factors that correlated both significantly and independently with elevation of CPK values: increased blood urea nitrogen level, low serum phosphate level, a stuporous or comatose state, tremor, and muscle tenderness. Myoglobinuria, detected in 14 patients, was predictive of a fatal outcome, but a high CPK level by itself was not an independent correlate of mortality. In summary, CPK elevation is not uncommon in febrile diseases, but because it does not reflect a specific etiology it does not necessarily indicate that an extensive diagnostic work-up is required.
AB - The incidence and significance of elevated serum levels of creatine phosphokinase (CPK) in febrile diseases were studied prospectively in all patients admitted with fever to a department of medicine during 1 year. High serum CPK levels were detected in 70 (28%) of 247 febrile patients but in only six (6%) of 105 afebrile control patients (P = .0001). Elevated CPK levels were not related to any specific diagnosis. Logistic regression analysis identified five factors that correlated both significantly and independently with elevation of CPK values: increased blood urea nitrogen level, low serum phosphate level, a stuporous or comatose state, tremor, and muscle tenderness. Myoglobinuria, detected in 14 patients, was predictive of a fatal outcome, but a high CPK level by itself was not an independent correlate of mortality. In summary, CPK elevation is not uncommon in febrile diseases, but because it does not reflect a specific etiology it does not necessarily indicate that an extensive diagnostic work-up is required.
UR - http://www.scopus.com/inward/record.url?scp=0026029392&partnerID=8YFLogxK
U2 - 10.1093/clinids/13.2.237
DO - 10.1093/clinids/13.2.237
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C2 - 2041954
AN - SCOPUS:0026029392
SN - 0162-0886
VL - 13
SP - 237
EP - 242
JO - Reviews of Infectious Diseases
JF - Reviews of Infectious Diseases
IS - 2
ER -