TY - JOUR
T1 - Significance of DNA Ploidy in the Treatment of T1 Glottic Carcinoma
AU - Stern, Yoram
AU - Aronson, Moshe
AU - Shpitzer, Thomas
AU - Nativ, Ofer
AU - Medalia, Ora
AU - Segal, Karl
AU - Feinmesser, Raphael
PY - 1995/9
Y1 - 1995/9
N2 - Objective: To assess the role of DNA ploidy as a predictor of radioresistance in T1, glottic carcinoma. Design: Case-control study. Flow cytometric DNA ploidy measurements were performed on formalin-fixed paraffin-embedded tumor specimens from 15 patients with T1 glottic laryngeal carcinomas in whom radiotherapy had failed and from a matched group of 15 patients in whom an identical radiotherapy regimen was curative. Analysis of DNA content was performed blind to outcome of treatment. Setting: Academic tertiary referral medical center. Participants: Thirty patients with clinically staged T1, N0, M0 glottic carcinoma. Intervention: All patients received radiation to the larynx through opposed lateral ports at a total dose of 64 to 70 Gy. Results: Ten diploid and five aneuploid histograms were found in the resistant group, and six diploid and nine aneuploid histograms were found in the radiosensitive group. This difference was not statistically significant. A trend toward a higher relapse rate after radiotherapy (62.5%) among patients with diploid tumor compared with those with aneuploid tumor (35.7%) was noted. Conclusions: DNA ploidy did not predict response to radiotherapy in patients with T1 glottic cancer, probably because of the small number of patients. A trend toward lower risk of local recurrence after radiotherapy in aneuploid tumors was noted. A larger prospective study is needed to assess the value of DNA ploidy in the treatment of early laryngeal cancer.
AB - Objective: To assess the role of DNA ploidy as a predictor of radioresistance in T1, glottic carcinoma. Design: Case-control study. Flow cytometric DNA ploidy measurements were performed on formalin-fixed paraffin-embedded tumor specimens from 15 patients with T1 glottic laryngeal carcinomas in whom radiotherapy had failed and from a matched group of 15 patients in whom an identical radiotherapy regimen was curative. Analysis of DNA content was performed blind to outcome of treatment. Setting: Academic tertiary referral medical center. Participants: Thirty patients with clinically staged T1, N0, M0 glottic carcinoma. Intervention: All patients received radiation to the larynx through opposed lateral ports at a total dose of 64 to 70 Gy. Results: Ten diploid and five aneuploid histograms were found in the resistant group, and six diploid and nine aneuploid histograms were found in the radiosensitive group. This difference was not statistically significant. A trend toward a higher relapse rate after radiotherapy (62.5%) among patients with diploid tumor compared with those with aneuploid tumor (35.7%) was noted. Conclusions: DNA ploidy did not predict response to radiotherapy in patients with T1 glottic cancer, probably because of the small number of patients. A trend toward lower risk of local recurrence after radiotherapy in aneuploid tumors was noted. A larger prospective study is needed to assess the value of DNA ploidy in the treatment of early laryngeal cancer.
UR - http://www.scopus.com/inward/record.url?scp=0029150430&partnerID=8YFLogxK
U2 - 10.1001/archotol.1995.01890090045009
DO - 10.1001/archotol.1995.01890090045009
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AN - SCOPUS:0029150430
SN - 0886-4470
VL - 121
SP - 1003
EP - 1005
JO - JAMA Otolaryngology - Head and Neck Surgery
JF - JAMA Otolaryngology - Head and Neck Surgery
IS - 9
ER -