Significance of Anteroseptal Late Gadolinium Enhancement Among Patients With Acute Myocarditis

Wesam Mulla, Amitai Segev, Amir Novak, Dean Yogev, Arsalan Abu-Much, Alexander Fardman, Eias Massalha, Orly Goietin, Raphael Kuperstein, Shlomi Matetzky, Avishay Grupper, Yoav Afel, Romana Herscovici, Yael Peled-Potashnik, Fernando Chernomordik, Yafim Brodov, Roy Beigel, Anan Younis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Anteroseptal location of late gadolinium enhancement (LGE) in patients with acute myocarditis (AM) detected by cardiovascular magnetic resonance may indicate an independent marker of unfavorable outcomes according to recent data. We aimed to evaluate the clinical characteristics, management, and inhospital outcomes in patients with AM with positive LGE based on its presence in the anteroseptal location. We analyzed data from 262 consecutive patients hospitalized with a diagnosis of AM with positive LGE within 5 days of hospitalization (n = 425). Patients were divided into 2 groups: those with anteroseptal LGE (n = 25, 9.5%) and those with non–anteroseptal LGE (n = 237, 90.5%). Except for age that was higher in patients with anteroseptal LGE, the demographic and clinical characteristics did not differ significantly between both groups including past medical history, clinical presentation, electrocardiogram parameters, and lab values. Moreover, patients with anteroseptal LGE were more likely to present with reduced left ventricular ejection fraction and to receive congestive heart failure treatments. Although univariate analysis showed that patients with anteroseptal LGE were more likely to have inhospital major adverse cardiac events (28% vs 9%, p = 0.003), there was no difference inhospital outcomes on multivariable analysis between both groups (hazard ratio, 1.17 [95% confidence interval, 0.32 to 4.22], p = 0.81). A higher left ventricular ejection fraction in either echocardiography or cardiovascular magnetic resonance corresponded to better inhospital outcomes regardless of the presence or absence of anteroseptal LGE. In conclusion, the presence of anteroseptal LGE did not confer additional prognostic value for inhospital outcomes.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalAmerican Journal of Cardiology
StatePublished - 15 Jul 2023


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