SIGNIFICANCE IN NEONATAL MYASTHENIA GRAVIS OF INHIBITORY EFFECT OF AMNIOTIC FLUID ON BINDING OF ANTIBODIES TO ACETYLCHOLINE RECEPTOR

Oded Abramsky, Robert P. Lisak, Talma Brenner, Aza Zeidman, Yoram Beyth

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of amniotic fluid on the binding of anti-acetylcholine receptor (anti-AChR) antibodies from myasthenia gravis (MG) patients to AChR preparations was examined by radioimmunoassay using 125I-labelled α-bungarotoxin. Human amniotic fluid from healthy women in their second trimester inhibited the in-vitro interaction between antibody and antigen. This finding suggests that during pregnancy there is a similar inhibitory effect in MG on the in-vivo binding of maternal anti-AChR antibodies, transferred through the placenta, to AChR at the fetal neuromuscular junction. The presence of feto-placental inhibitory factors may explain the development of transitory muscular weakness only after birth and only in the minority of the babies born to myasthenic mothers.

Original languageEnglish
Pages (from-to)1333-1335
Number of pages3
JournalThe Lancet
Volume314
Issue number8156-8157
DOIs
StatePublished - 29 Dec 1979
Externally publishedYes

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