Signalling in mammalian egg activation: Role of protein kinases

Anat Talmor-Cohen, Efrat Eliyahu, Ruth Shalgi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Embryonic development is initiated after the fertilizing spermatozoon enters the egg and triggers a process known as 'egg activation'. Activation results in an increase in intracellular calcium concentration, cortical granule exocytosis (CGE), cell cycle resumption and recruitment of maternal mRNA. Various treatments can induce parthenogenetic activation characterized by the same manifestations. Signal transduction pathways similar to those known for somatic cells mediate the mammalian egg activation. This review focuses on the signal transduction pathways that occur during mammalian fertilization and during parthenogenetic egg activation. We discuss the possibility that members of the protein tyrosine kinase (PTKs) families, the Src family PTKs in particular, operate during egg activation and that protein kinase C can induce CGE.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalMolecular and Cellular Endocrinology
Issue number1-2
StatePublished - 22 Feb 2002


FundersFunder number
Israel Science Foundation


    • Egg activation
    • Mammals
    • Signal transduction


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