Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: Cross-talk of calcium, protein kinase C (PKC), and arachidonic acid

Zvi Naor, Sharon Shacham, Dagan Harris, Rony Seger, Nachum Reiss

Research output: Contribution to journalArticlepeer-review

Abstract

1. The decapeptide neurohormone gonadotropin releasing hormone (GnRH) is the first key hormone of the reproductive system. Produced in the hypothalamus, GnRH is released in a pulsatile manner into the hypophysial portal system to reach the anterior pituitary and stimulates the release and synthesis of the gonadotropin hormones LH and FSH. GnRH, a Ca2+ mobilizing ligand, binds to its respective binding protein, which is a member of the seven transmembrane domain receptor family and activates a G-protein (Gq). 2. The α subunit of Gq triggers enhanced phosphoinositide turnover and the elevation of multiple second messengers required for gonadotropin release and biosynthesis. 3. The messenger molecules IP3, diacylglycerol, Ca2+, protein kinase C, arachidonic acid and leukotriene C4 cross-talk in a complex networks of signaling, culminating in gonadotropin release and gene expression.

Original languageEnglish
Pages (from-to)527-544
Number of pages18
JournalCellular and Molecular Neurobiology
Volume15
Issue number5
DOIs
StatePublished - Oct 1995

Keywords

  • G-proteins
  • GnRH
  • GnRH receptor
  • IP
  • MAP kinase
  • arachidonic acid
  • calcium
  • diacyl-glycerol, leukotrienes
  • follicle stimulating hormone (FSH)
  • inositol phosphates
  • luteinizing hormone (LH)
  • protein kinase C (PKC)

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