TY - JOUR
T1 - Signal transduction of the gonadotropin releasing hormone (GnRH) receptor
T2 - Cross-talk of calcium, protein kinase C (PKC), and arachidonic acid
AU - Naor, Zvi
AU - Shacham, Sharon
AU - Harris, Dagan
AU - Seger, Rony
AU - Reiss, Nachum
PY - 1995/10
Y1 - 1995/10
N2 - 1. The decapeptide neurohormone gonadotropin releasing hormone (GnRH) is the first key hormone of the reproductive system. Produced in the hypothalamus, GnRH is released in a pulsatile manner into the hypophysial portal system to reach the anterior pituitary and stimulates the release and synthesis of the gonadotropin hormones LH and FSH. GnRH, a Ca2+ mobilizing ligand, binds to its respective binding protein, which is a member of the seven transmembrane domain receptor family and activates a G-protein (Gq). 2. The α subunit of Gq triggers enhanced phosphoinositide turnover and the elevation of multiple second messengers required for gonadotropin release and biosynthesis. 3. The messenger molecules IP3, diacylglycerol, Ca2+, protein kinase C, arachidonic acid and leukotriene C4 cross-talk in a complex networks of signaling, culminating in gonadotropin release and gene expression.
AB - 1. The decapeptide neurohormone gonadotropin releasing hormone (GnRH) is the first key hormone of the reproductive system. Produced in the hypothalamus, GnRH is released in a pulsatile manner into the hypophysial portal system to reach the anterior pituitary and stimulates the release and synthesis of the gonadotropin hormones LH and FSH. GnRH, a Ca2+ mobilizing ligand, binds to its respective binding protein, which is a member of the seven transmembrane domain receptor family and activates a G-protein (Gq). 2. The α subunit of Gq triggers enhanced phosphoinositide turnover and the elevation of multiple second messengers required for gonadotropin release and biosynthesis. 3. The messenger molecules IP3, diacylglycerol, Ca2+, protein kinase C, arachidonic acid and leukotriene C4 cross-talk in a complex networks of signaling, culminating in gonadotropin release and gene expression.
KW - G-proteins
KW - GnRH
KW - GnRH receptor
KW - IP
KW - MAP kinase
KW - arachidonic acid
KW - calcium
KW - diacyl-glycerol, leukotrienes
KW - follicle stimulating hormone (FSH)
KW - inositol phosphates
KW - luteinizing hormone (LH)
KW - protein kinase C (PKC)
UR - http://www.scopus.com/inward/record.url?scp=0029557561&partnerID=8YFLogxK
U2 - 10.1007/BF02071315
DO - 10.1007/BF02071315
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AN - SCOPUS:0029557561
SN - 0272-4340
VL - 15
SP - 527
EP - 544
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
IS - 5
ER -