TY - JOUR
T1 - Signal-induced parp1-erk synergism mediates ieg expression
AU - Cohen-Armon, Malka
AU - Yeheskel, Adva
AU - Pascal, John M.
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019
Y1 - 2019
N2 - A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra-and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy.
AB - A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra-and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy.
UR - http://www.scopus.com/inward/record.url?scp=85075521250&partnerID=8YFLogxK
U2 - 10.1038/s41392-019-0042-0
DO - 10.1038/s41392-019-0042-0
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AN - SCOPUS:85075521250
SN - 2095-9907
VL - 4
JO - Signal Transduction and Targeted Therapy
JF - Signal Transduction and Targeted Therapy
IS - 1
M1 - 8
ER -