Side effects of long-term treatment with fluoxetine

Nili Buchman, Rael D. Strous*, Yehuda Baruch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Depressive disorders are frequently managed with long-term use of antidepressant medication. Even though the newer generation of selective serotonin reuptake inhibitor antidepressants exhibits a more favorable short-term, side-effect profile, effects of chronic use of such drugs remain unknown. Considering the limited data available on long-term, selective serotonin reuptake inhibitor management, we report for the first time on two cases of late-onset adverse effects occurring 6 and 10 years after chronic-fluoxetine treatment in which patients experienced symptoms of restlessness, tension, agitation, and sleep disturbances. Symptoms resolved after reduction or cessation of the medication. Our case reports suggest the existence of a late-onset side-effect profile, which appears similar to acute side-effect symptomatology. Super sensitivity of the serotonin-related receptors may develop over the long-term and account for the phenomenon. Careful clinical monitoring is recommended to detect any late-onset, medication-related side effects.

Original languageEnglish
Pages (from-to)55-57
Number of pages3
JournalClinical Neuropharmacology
Issue number1
StatePublished - 2002
Externally publishedYes


  • Fluoxetine
  • Long-term
  • Selective serotonin reuptake inhibitor
  • Side effects


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