TY - JOUR
T1 - Side effects of long-term treatment with fluoxetine
AU - Buchman, Nili
AU - Strous, Rael D.
AU - Baruch, Yehuda
PY - 2002
Y1 - 2002
N2 - Depressive disorders are frequently managed with long-term use of antidepressant medication. Even though the newer generation of selective serotonin reuptake inhibitor antidepressants exhibits a more favorable short-term, side-effect profile, effects of chronic use of such drugs remain unknown. Considering the limited data available on long-term, selective serotonin reuptake inhibitor management, we report for the first time on two cases of late-onset adverse effects occurring 6 and 10 years after chronic-fluoxetine treatment in which patients experienced symptoms of restlessness, tension, agitation, and sleep disturbances. Symptoms resolved after reduction or cessation of the medication. Our case reports suggest the existence of a late-onset side-effect profile, which appears similar to acute side-effect symptomatology. Super sensitivity of the serotonin-related receptors may develop over the long-term and account for the phenomenon. Careful clinical monitoring is recommended to detect any late-onset, medication-related side effects.
AB - Depressive disorders are frequently managed with long-term use of antidepressant medication. Even though the newer generation of selective serotonin reuptake inhibitor antidepressants exhibits a more favorable short-term, side-effect profile, effects of chronic use of such drugs remain unknown. Considering the limited data available on long-term, selective serotonin reuptake inhibitor management, we report for the first time on two cases of late-onset adverse effects occurring 6 and 10 years after chronic-fluoxetine treatment in which patients experienced symptoms of restlessness, tension, agitation, and sleep disturbances. Symptoms resolved after reduction or cessation of the medication. Our case reports suggest the existence of a late-onset side-effect profile, which appears similar to acute side-effect symptomatology. Super sensitivity of the serotonin-related receptors may develop over the long-term and account for the phenomenon. Careful clinical monitoring is recommended to detect any late-onset, medication-related side effects.
KW - Fluoxetine
KW - Long-term
KW - Selective serotonin reuptake inhibitor
KW - Side effects
UR - http://www.scopus.com/inward/record.url?scp=0036182958&partnerID=8YFLogxK
U2 - 10.1097/00002826-200201000-00010
DO - 10.1097/00002826-200201000-00010
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C2 - 11852298
AN - SCOPUS:0036182958
SN - 0362-5664
VL - 25
SP - 55
EP - 57
JO - Clinical Neuropharmacology
JF - Clinical Neuropharmacology
IS - 1
ER -