Sialyltransferase activity in AF10 myeloma cell line

A. M. Cohen*, D. Allalouf, T. Wacks, N. Lehrer, H. Levinsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A STA was observed in a human-derived myeloma cell line, AF10, that produces IgE paraprotein. The STA in the culture medium of the AF10 myeloma cell line was associated in the 24 to 48 hr period of incubation with IgE biosynthesis, and increased thereafter up to 72 hr, while IgE remained stable. These data support our previous observations that human myeloma cells are associated with a relatively high production of sialyltransferase, which is released to the medium, presumably by a mechanism of shedding.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalBiochemical Medicine and Metabolic Biology
Volume44
Issue number2
DOIs
StatePublished - Oct 1990
Externally publishedYes

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