Sialic acid sialyltransferase activity in testis, epididymis and prostate of rats: Developmental stages

R. Singer, R. Weissenber, M. Lahav, M. Sagiv, P. Raanani, S. Kyzer, A. M. Cohen, H. Levinsky

Research output: Contribution to journalArticlepeer-review

Abstract

Sialic acid content and sialyltransferase activity were evaluated in rat testis, epididymis and prostate in relation to age (21,55,82 and 135 days). Sialic acid, estimated in tissue homogenates was expressed as ug per mg protein powder and per g tissue. Sialyltransferase activity was evaluated using radioactivity incorporated of CMP (14C sialic acid) and expressed as cpm per 167mg tissue. Sialic acid content in testis decreased with age while in the epididymis an opposite trend was observed. Sialic acid content in the epididymis was, in the majority of experiments, significantly higher than in testis. The activity of sialyltransferase in testis, epididymis and prostate exhibited a tendency to decrease with age. In the epididymis the activity was 5-7 times higher than in testis at all age groups and 8-17 times higher than in the prostate 955,82,135 days). It would appear that both the content of sialic acid and sialyltransferase activity correlate with the metabolic rates of sialoglycoproteins and sialoglycolipids of the examined tissue, as well as with sperm production. This may have considerable significance in the development of male contraceptive technology.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalAdvances in Contraceptive Delivery Systems
Volume8
Issue number3
StatePublished - 1992

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