Sialic acid level in maternal and neonatal lymphocytes and sera correlated to birth order and sex of the neonate

L. Komlos*, J. Landmann, J. Notmann, F. Dulitzky, S. Kyzer, J. Hart, I. Halbrecht, H. Levinsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Sialic acid (N-acetylneuraminic acid) was determined 1 h after normal term deliveries on peripheral blood lymphocytes from 42 mother-neonate pairs and in 29 maternal and neonatal sera. Results were evaluated according to maternal parity and sex of the neonate. The cases were divided into two groups: primiparae, and secundi- and multiparae. In primiparae the sialic acid level on lymphocytes from male neonates and from their mothers was by 23-30% decreased as compared to female neonatal and maternal cells. In the higher parity group. a significantly increased sialic acid level was found on lymphocytes from male as compared to female neonates, and maternal serum sialic acid concentration, unrelated to the newborns' sex, was by 17-20% increased as compared to primiparae. The results suggest that with increasing parity higher levels of sialic acid on male neonatal cells may possibly contribute to mask fetal male-specific histocompatibility antigens. Increased sialic acid levels in maternal sera from secundi- and multiparae suggest its possible contribution to an increased serum blocking effect.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalNeonatology
Volume62
Issue number6
DOIs
StatePublished - 1992

Keywords

  • Maternal lymphocytes
  • Neonatal lymphocytes
  • Parity
  • Sialic acid
  • Y correlated histocompatibility antigens

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