Sialic acid in platelets of schizophrenic patients

Pinkhas Sirota, Hanna Bessler, David Allalouf, Meir Djaldetti, Haim Levinsky

Research output: Contribution to journalArticlepeer-review

Abstract

Sirota, Pinkhas, Hanna Bessler, David Allalouf, Meir Djaldetti and Haim Levinsky: Sialic acid in platelets of schizophrenic patients. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1988, 12: 103-107. 1. 1. Nerve cell membrane sialic acid is involved in the activity of nervous tissue by its capacity to bind Ca ions and positively charged biogenic amines. 2. 2. Blood platelets may serve as a model for amine-storing neurons. 3. 3. The purpose of the present study was to determine the sialic acid content of platelets of schizophrenic patients in view of reports showing a reduced serotonin uptake by their platelets. 4. 4. To this end platelets were isolated from the blood of 26 schizophrenic patients (13 males and 13 females) of various diagnostic subtypes and from 21 healthy subjects, and sialic acid was determined after hydrolysis at 80 ° for 1 h in 0.1 NHCl. 5. 5. The results showed significantly lower contents of sialic acid in the patients as compared to controls calculated both per 108 cells and per mg protein (18% and 25% lower, respectively) and appear to be in line with the reduced serotonin uptake in their cells in schizophrenia. 6. 6. There were no appreciable differences between sexes and between the various subtypes of this disease.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume12
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • platelets
  • schizophrenic patients
  • sialic acid

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