Short Training Significantly Improves Ganglion Cell Detection Using an Algorithm-Assisted Approach

Ariel Greenberg, Benzion Samueli, Ibrahim Fahoum, Shai Farkash, Orli Greenberg, Valentina Zemser-Werner, Edmond Sabo, Rami R. Hagege, Dov Hershkovitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Context.—Medical education in pathology relies on the accumulation of experience gained through inspection of numerous samples from each entity. Acquiring sufficient teaching material for rare diseases, such as Hirschsprung disease (HSCR), may be difficult, especially in smaller institutes. The current study makes use of a previously developed decision support system using a decision support algorithm meant to aid pathologists in the diagnosis of HSCR. Objective.—To assess the effect of a short training session on algorithm-assisted HSCR diagnosis. Design.—Five pathologists reviewed a data set of 568 image sets (1704 images in total) selected from 50 cases by the decision support algorithm and were tasked with scoring the images for the presence or absence of ganglion cells. The task was repeated a total of 3 times. Each pathologist had to complete a short educational presentation between the second and third iterations. Results.—The training resulted in a significantly increased rate of correct diagnoses (true positive/negative) and a decreased need for referrals for expert consultation. No statistically significant changes in the rate of false positives/negatives were detected. Conclusions.—A very short (,10 minutes) training session can greatly improve the pathologist’s performance in the algorithm-assisted diagnosis of HSCR. The same approach may be feasible in training for the diagnosis of other rare diseases.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Issue number2
StatePublished - Feb 2023


FundersFunder number
Israeli Innovation Authority


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