Short-term treatment of post-traumatic stress disorder with naltrexone: An open-label preliminary study

Gad Lubin, Abraham Weizman, Mordechai Shmushkevitz, Avi Valevski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Eight patients (6 men and 2 women) with chronic post-traumatic stress disorder (PTSD) were treated with naltrexone 100-200 mg/day. Seven patients completed 2 weeks of treatment. A subtle and clinically insignificant improvement was noted in intrusive and hyperarousal symptoms (p < 0.05 for both), but not in avoidance symptoms. All patients demonstrated side effects which limited the targeted dose. It is suggested that the subtle positive effect of naltrexone and the hypersensitivity of these patients to its side effects do not encourage the use of naltrexone in the treatment of PTSD patients.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalHuman Psychopharmacology
Volume17
Issue number4
DOIs
StatePublished - 2002

Keywords

  • Anxiety
  • Naltrexone
  • Opioid system
  • Post-traumatic stress disorder

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