Short-term effect of prebiotics administration on stool characteristics and serum cytokines dynamics in very young children with acute diarrhea

Nachum Vaisman, Josef Press, Eugene Leibovitz, Güenther Boehm, Vivian Barak

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the effect of a mixture of long-chain fructo-oligosaccharides, galacto-oligosaccharides and acidic oligosaccharides on the number and consistency of stools and on immune system biomarkers in 104 supplemented and non-supplemented subjects (aged 9-24 months) with acute diarrhea. Interleukin-1 (IL-1), IL-1RA, IL-6, IL-8, IL-10, TNF-α and sIL-2R cytokine levels were determined. The significant decrease in number of stools and increase in stool consistency in the supplemented group was of little clinical relevance. The only significant change in pro- and anti-inflammatory cytokines was decreased TNF-α levels in the supplemented group. Prebiotic supplementation during acute diarrhea episodes did not influence the clinical course.

Original languageEnglish
Pages (from-to)683-692
Number of pages10
JournalNutrients
Volume2
Issue number7
DOIs
StatePublished - Jul 2010

Keywords

  • Cytokines
  • Diarrhea
  • Fructo-oligosaccharides
  • Galacto-oligosaccharides
  • Galacturonic oligosaccharides
  • Infants
  • Prebiotics

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