Short-term auditory priming in freely-moving mice

Shir Sivroni; Hadas E. Sloin; Eran Stark

doi:10.1016/j.isci.2023.107847

Short-term auditory priming in freely-moving mice

Shir Sivroni, Hadas E. Sloin, Eran Stark^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Priming, a change in the mental processing of a stimulus as a result of prior encounter with a related stimulus, has been observed repeatedly and studied extensively in humans. Yet currently, there is no behavioral model of short-term priming in lab animals, precluding research on the neurobiological basis of priming. Here, we describe an auditory discrimination paradigm for studying response priming in freely moving mice. We find a priming effect in success rate in all mice tested on the task. In contrast, we do not find a priming effect in response times. Compared to non-primed discrimination trials, the addition of incongruent prime stimuli reduces success rate more than congruent prime stimuli, suggesting a cognitive mechanism based on differential interference. The results establish the short-term priming phenomenon in rodents, and the paradigm opens the door to studying the cellular-network basis of priming.

Original language	English
Article number	107847
Journal	iScience
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.isci.2023.107847
State	Published - 20 Oct 2023

Funding

Funders	Funder number
Israel Science Foundation
International Development Research Centre
Liad Mudrik and Israel Nelken
Canadian Institutes of Health Research
European Research Council
Horizon 2020 Framework Programme	679253
Azrieli Foundation	2558/18

Keywords

Behavioral neuroscience
Sensory neuroscience

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10.1016/j.isci.2023.107847

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Short-term auditory priming in freely-moving mice

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