Short-term auditory priming in freely-moving mice

Shir Sivroni; Hadas E. Sloin; Eran Stark

doi:10.1016/j.isci.2023.107847

Short-term auditory priming in freely-moving mice

Shir Sivroni, Hadas E. Sloin, Eran Stark^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Priming, a change in the mental processing of a stimulus as a result of prior encounter with a related stimulus, has been observed repeatedly and studied extensively in humans. Yet currently, there is no behavioral model of short-term priming in lab animals, precluding research on the neurobiological basis of priming. Here, we describe an auditory discrimination paradigm for studying response priming in freely moving mice. We find a priming effect in success rate in all mice tested on the task. In contrast, we do not find a priming effect in response times. Compared to non-primed discrimination trials, the addition of incongruent prime stimuli reduces success rate more than congruent prime stimuli, suggesting a cognitive mechanism based on differential interference. The results establish the short-term priming phenomenon in rodents, and the paradigm opens the door to studying the cellular-network basis of priming.

Original language	English
Article number	107847
Journal	iScience
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.isci.2023.107847
State	Published - 20 Oct 2023

Funding

Funders	Funder number
Liad Mudrik and Israel Nelken
Canadian Institutes of Health Research
International Development Research Centre
European Research Council	679253
Israel Science Foundation
Azrieli Foundation	2558/18

Keywords

Behavioral neuroscience
Sensory neuroscience

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10.1016/j.isci.2023.107847

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Short-term auditory priming in freely-moving mice

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