Short-term auditory priming in freely-moving mice

Shir Sivroni, Hadas E. Sloin, Eran Stark*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Priming, a change in the mental processing of a stimulus as a result of prior encounter with a related stimulus, has been observed repeatedly and studied extensively in humans. Yet currently, there is no behavioral model of short-term priming in lab animals, precluding research on the neurobiological basis of priming. Here, we describe an auditory discrimination paradigm for studying response priming in freely moving mice. We find a priming effect in success rate in all mice tested on the task. In contrast, we do not find a priming effect in response times. Compared to non-primed discrimination trials, the addition of incongruent prime stimuli reduces success rate more than congruent prime stimuli, suggesting a cognitive mechanism based on differential interference. The results establish the short-term priming phenomenon in rodents, and the paradigm opens the door to studying the cellular-network basis of priming.

Original languageEnglish
Article number107847
JournaliScience
Volume26
Issue number10
DOIs
StatePublished - 20 Oct 2023

Funding

FundersFunder number
Israel Science Foundation
International Development Research Centre
Liad Mudrik and Israel Nelken
Canadian Institutes of Health Research
European Research Council
Horizon 2020 Framework Programme679253
Azrieli Foundation2558/18

    Keywords

    • Behavioral neuroscience
    • Sensory neuroscience

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