TY - JOUR
T1 - Short-term auditory priming in freely-moving mice
AU - Sivroni, Shir
AU - Sloin, Hadas E.
AU - Stark, Eran
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/10/20
Y1 - 2023/10/20
N2 - Priming, a change in the mental processing of a stimulus as a result of prior encounter with a related stimulus, has been observed repeatedly and studied extensively in humans. Yet currently, there is no behavioral model of short-term priming in lab animals, precluding research on the neurobiological basis of priming. Here, we describe an auditory discrimination paradigm for studying response priming in freely moving mice. We find a priming effect in success rate in all mice tested on the task. In contrast, we do not find a priming effect in response times. Compared to non-primed discrimination trials, the addition of incongruent prime stimuli reduces success rate more than congruent prime stimuli, suggesting a cognitive mechanism based on differential interference. The results establish the short-term priming phenomenon in rodents, and the paradigm opens the door to studying the cellular-network basis of priming.
AB - Priming, a change in the mental processing of a stimulus as a result of prior encounter with a related stimulus, has been observed repeatedly and studied extensively in humans. Yet currently, there is no behavioral model of short-term priming in lab animals, precluding research on the neurobiological basis of priming. Here, we describe an auditory discrimination paradigm for studying response priming in freely moving mice. We find a priming effect in success rate in all mice tested on the task. In contrast, we do not find a priming effect in response times. Compared to non-primed discrimination trials, the addition of incongruent prime stimuli reduces success rate more than congruent prime stimuli, suggesting a cognitive mechanism based on differential interference. The results establish the short-term priming phenomenon in rodents, and the paradigm opens the door to studying the cellular-network basis of priming.
KW - Behavioral neuroscience
KW - Sensory neuroscience
UR - http://www.scopus.com/inward/record.url?scp=85171365585&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2023.107847
DO - 10.1016/j.isci.2023.107847
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C2 - 37736050
AN - SCOPUS:85171365585
SN - 2589-0042
VL - 26
JO - iScience
JF - iScience
IS - 10
M1 - 107847
ER -