Short- and long-term complications of in utero exposure to lamotrigine

Merav Cohen-Israel, Itai Berger, Einat Y. Martonovich, Gil Klinger, Bracha Stahl, Nehama Linder

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: The present study evaluates the effect of antenatal lamotrigine exposure, on short- and long-term paediatric outcome. Methods: The study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary medical centre between 2004–2014. All newborns were monitored for vital signs, congenital malformations and Finnegan score. In addition, the parents completed a questionnaire regarding their child's development and health up to the age of 12 years. Results: No major malformations were found in the newborns. None of the newborns had significant withdrawal symptoms by Finnegan score. The children were followed-up to the age of 12 years (56.6% were 6–12 years at the time of evaluation). There were no significant findings in the incidence of neurodevelopmental disorders. Conclusions: According to our experience, lamotrigine is generally safe for pregnancy use, associated with minimal short-term complications with no long-term effects on the outcome.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume84
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • in utero
  • lamotrigine
  • neonatal
  • neurodevelopmental
  • outcome
  • pregnancy

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