Shifting Strategies in the Treatment of Pediatric Craniopharyngioma

Segev Gabay, Thomas E. Merchant, Frederick A. Boop, Jonathan Roth, Shlomi Constantini*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: Craniopharyngiomas represent one of the most challenging diseases to treat. Despite their benign histology, and after many decades of surgical experience and technological advancements, there is still no clear consensus regarding the most effective management for this tumor. Due to their location and aggressive local characteristics, purely surgical approaches all too often result in unacceptable morbidity. Recent Findings: Partial resection combined with radiation therapy results in similar control rates when compared to aggressive surgery, while also minimalizing the neuro-endocrinological morbidity. Summary: In this manuscript, we describe the historical progression of the shifting strategies in the management of pediatric craniopharyngioma. Time has also altered our expectations for outcomes, evolving from purely morbidity and mortality to simple Glasgow Outcomes Scales, now to formal neuro-psychometric and quality of life data.

Original languageEnglish
Pages (from-to)1497-1513
Number of pages17
JournalCurrent Oncology Reports
Volume25
Issue number12
DOIs
StatePublished - Dec 2023

Keywords

  • Blindness
  • Brain tumor
  • Craniopharyngioma
  • Endoscopy
  • Hydrocephalus
  • Minimally invasive treatment
  • Morbidity
  • Pediatric
  • Protons
  • Radiotherapy

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