Shapes and structures of biological rhythms: Variability of phenotypes in two strains of mice and their progeny

Yuval Weigl, Israel E. Ashkenazi, Aviva Dotan, Leah Peleg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The patterns of creatine-phosphokinase and alkaline-phosphatase activities, white blood cells counts and urea-nitrogen concentration were assessed in males and females of two mice strains (BALB/c, c57BL/6J) and in their one-sided cross F1 progeny. All animals were exposed to a 12:12 light:dark regimen. The patterns were analyzed to elucidate the rhythm basic parameters: period, acrophase, mesor and amplitude and three additional characteristics: relative amplitude, rate of change of the relative amplitude and the area under the curve. Analysis of the rhythms' structure showed that most patterns possess more than one period component (compound rhythms). Strain and gender differences were revealed in some patterns even under identical environmental signals. The versatility of the F1 group patterns suggests that each parameter is governed by separate multiple or polygenic systems. Such organization enables multitude phenotypes of compound rhythms which endows the organism with physiological advantage by optimizing its functions to cope with a multitude of environmental signals.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalBiological Rhythm Research
Volume41
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • Biological rhythm
  • Entrainment
  • Genetic variations
  • Inheritance modes

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