Sh. dysenteriae serotypes 2,4,8 immunochemistry and phage receptor activity

J. Goldhar, C. Barbar, E. Eylan

Research output: Contribution to journalArticlepeer-review


Among 3 analyzed serotypes of Shigella dysenteriae, namely, the serotypes 2, 4 and 8, the serotype 2 proved to be a strong immunogen in rabbits, inducing anti polysaccharide antibodies as well as antiprotein antibodies in all the animals. In contrast, the serotypes 4 and 8 were weak immunogens and among the rabbits some have synthesized only antiproteins while others had antibodies against the somatic conjugate. Aside from the somatic antigens, large amounts of proteins were isolated from all the strains; however, the numerous determinants of these proteins were proven with the help of a serum to proteins from S. sonnei. The polysaccharides were specific for the serotype. The sensitivity of S. dysenteriae strains to phage P1 and the phage receptor activity of different bacterial extracts were examined. By using the phage receptor neutralization test, it was possible to demonstrate that the receptor substance is a common component present in the lipopolysaccharide. The nature of neutralization has been discussed.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
Issue number1
StatePublished - 1976


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