Sexually dimorphic anthropometric measurements in patients with hypospadias and cryptorchidism

Yoav Uchitel*, Osnat Zmora, Ilia Beberashvili, Marianna Rachmiel, Yakaterina Visman, Amos Neheman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Inappropriate exposure or activity of sex hormones in-utero has been postulated as a leading cause for the development of hypospadias and cryptorchidism. Anthropometric sexually dimorphic traits such as the 2nd to 4th digit ratio (2D:4D), anogenital distance (AGD) and the stretched penile length (SPL), have been associated with androgen and estrogen activity in-utero. Purpose: Evaluate anthropometric parameters in patients with hypospadias or cryptorchi-dism compared with healthy controls. Materials and methods: This is a case control study of male patients operated on between 2019 and 2020. Three groups were included: Hypospadias, cryptorchidism and a demographically similar control group. Anthropometric parameters 2D:4D, AGD and SPL were measured intra-operatively and compared between the groups. Results: Included in the study were 179 pediatric patients between the ages of 9–15 months (58 patients with hypo-spadias, 69 with cryptorchidism and 47 controls). There was no difference in AGD, 2D:4D and SPL between patients with cryptorchidism, hypospadias and controls. Conclusions: Anthropometric characteristics associated with androgen activity in utero were not different in patients with hypospadias and cryptorchidism compared with controls.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalAnthropologischer Anzeiger
Issue number3
StatePublished - 2023


  • anogenital distance
  • anthropometric parameters
  • cryptorchidism
  • hypospadias
  • second to fourth digit ratio
  • sexually dimorphic traits
  • stretched penile length


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