Fifty-nine uremic patients (38 males and 21 females) maintained on chronic hemodialysis (CHD) served as the subjects in a study of the relationship between sexual dysfunction and serum prolactin levels (SPL). Sexual desire and activity were evaluated by a self-report sexual function rating scale (SFRS). About half the population of this study reported sexual dysfunction. Males and females reporting disturbance of sexual function had significantly higher SPL than those with normal sexual funtion. Bromocriptine treatment in five hyperprolactinemic patients reduced SPL to normal range and improved the sexual funtion. Association between sexual dysfuntion and hyperprolactinemia in uremic patients is suggested.