@article{3a77339e8d334858a15d88f27b62c850,
title = "Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus",
abstract = "Activity-dependent neuroprotective protein (ADNP) is a highly conserved vasoactive intestinal peptide (VIP) responsive gene that is expressed abundantly in the brain and in the body and is essential for brain formation and embryonic development. Since, VIP exhibits sexual dimorphism in the hypothalamus, the potential differential expression of ADNP in male and female mice was investigated. Real-time polymerase chain reaction revealed sexual dimorphism in ADNP mRNA expression as well as fluctuations within the estrus cycle. Immunohistochemistry with an antibody to ADNP showed specific staining in the arcuate nucleus of the hypothalamus. ADNP-like immunoreactivity in the arcuate nucleus also exhibited fluctuations during the estrus cycle. Here, brain sections at proestrus were the most immunoreactive and brain sections at estrus - the least. Furthermore, male arcuate nucleus ADNP-like immunoreactivity was significantly lower than that of the female estrus. Many neuropeptides, neurotransmitters and proteins are localized to the arcuate nucleus where they contribute to the regulation of reproductive cyclicity and energy homeostasis. The results presented here suggest that ADNP has a part in the estrus cycle as an affecter or an effector.",
keywords = "ADNP, Hypothalamus, Sexual dimorphism, VIP",
author = "Sharon Furman and Hill, {Joanna M.} and Inna Vulih and Roy Zaltzman and Hauser, {Janet M.} and Brenneman, {Douglas E.} and Illana Gozes",
note = "Funding Information: The authors would like to thank Dr. Eli Giladi, Mr. D. T. Abede, Mr. D. Dangoor, Mr. S. Mandel, and Ms. I. Pilzer for their help. This study is in partial fulfillment of the requirements for the Ph.D. thesis work of Ms. Sharon Furman. This work was supported in part by the U.S.–Israel Binational Science Foundation, the Neufeld Memorial Award, the NIH-Tel Aviv University Student Exchange Program in Women Health, The Israel Science Foundation, Allon Therapeutics, Inc., the Institute for the Study of Aging and the Dr. Diana and Zyga Elton Fund. Prof. Illana Gozes is the incumbent of the Lily and Avraham Gildor Chair for the Investigation of Growth Factors.",
year = "2004",
month = dec,
day = "13",
doi = "10.1016/j.neulet.2004.09.077",
language = "אנגלית",
volume = "373",
pages = "73--78",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",
}