TY - JOUR
T1 - Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
AU - The MoTrPAC Study Group
AU - Many, Gina M.
AU - Sanford, James A.
AU - Sagendorf, Tyler J.
AU - Hou, Zhenxin
AU - Nigro, Pasquale
AU - Whytock, Katie L.
AU - Amar, David
AU - Caputo, Tiziana
AU - Gay, Nicole R.
AU - Gaul, David A.
AU - Hirshman, Michael F.
AU - Jimenez-Morales, David
AU - Lindholm, Malene E.
AU - Muehlbauer, Michael J.
AU - Vamvini, Maria
AU - Bergman, Bryan C.
AU - Fernández, Facundo M.
AU - Goodyear, Laurie J.
AU - Hevener, Andrea L.
AU - Ortlund, Eric A.
AU - Sparks, Lauren M.
AU - Xia, Ashley
AU - Adkins, Joshua N.
AU - Bodine, Sue C.
AU - Newgard, Christopher B.
AU - Schenk, Simon
AU - Armenteros, Jose Juan Almagro
AU - Amper, Mary Anne S.
AU - Ashley, Euan
AU - Asokan, Aneesh Kumar
AU - Avila-Pacheco, Julian
AU - Bae, Dam
AU - Bamman, Marcas M.
AU - Bararpour, Nasim
AU - Barnes, Jerry
AU - Buford, Thomas W.
AU - Burant, Charles F.
AU - Carbone, Nicholas P.
AU - Carr, Steven A.
AU - Chambers, Toby L.
AU - Chavez, Clarisa
AU - Chiu, Roxanne
AU - Clish, Clary B.
AU - Cutter, Gary R.
AU - Dasari, Surendra
AU - Dennis, Courtney
AU - Evans, Charles R.
AU - Fernandez, Facundo M.
AU - Gagne, Nicole
AU - Ge, Yongchao
N1 - Publisher Copyright:
© Battelle Memorial Institute 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.
AB - Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.
UR - http://www.scopus.com/inward/record.url?scp=85191967638&partnerID=8YFLogxK
U2 - 10.1038/s42255-023-00959-9
DO - 10.1038/s42255-023-00959-9
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 38693320
AN - SCOPUS:85191967638
SN - 2522-5812
VL - 6
SP - 963
EP - 979
JO - Nature Metabolism
JF - Nature Metabolism
IS - 5
ER -