TY - JOUR
T1 - Sex-related differences in patients' responses to heart failure therapy
AU - Barsheshet, Alon
AU - Brenyo, Andrew
AU - Goldenberg, Ilan
AU - Moss, Arthur J.
N1 - Funding Information:
A. Barsheshet’s research is partly supported by funding from the Mirowski–Moss Career Development Award. I. Goldenberg’s research is partly supported by the Mirowski Family Foundation.
PY - 2012/4
Y1 - 2012/4
N2 - Men and women with heart failure display important differences in clinical characteristics that might affect their responses to pharmacological and nonpharmacological therapies. In women, heart failure is associated with a higher frequency of hypertension, nonischemic cardiomyopathy and left bundle branch block than in men. Subgroup analyses of data from randomized clinical trials suggest that these differences result in a differential response to heart failure therapies, including a somewhat better response to β-blockers, a worse prognosis with digoxin therapy, and a lower survival benefit with implantable cardioverter-defibrillators in women. Importantly, female patients with heart failure also derive significantly greater improvements in cardiac volumes from cardiac resynchronization therapy than do male patients, and this treatment is associated with reduced risks of all-cause mortality and heart failure events among women with mild symptoms. These data suggest that sex-related differences might exist in response to both medical and device therapies for patients with heart failure.
AB - Men and women with heart failure display important differences in clinical characteristics that might affect their responses to pharmacological and nonpharmacological therapies. In women, heart failure is associated with a higher frequency of hypertension, nonischemic cardiomyopathy and left bundle branch block than in men. Subgroup analyses of data from randomized clinical trials suggest that these differences result in a differential response to heart failure therapies, including a somewhat better response to β-blockers, a worse prognosis with digoxin therapy, and a lower survival benefit with implantable cardioverter-defibrillators in women. Importantly, female patients with heart failure also derive significantly greater improvements in cardiac volumes from cardiac resynchronization therapy than do male patients, and this treatment is associated with reduced risks of all-cause mortality and heart failure events among women with mild symptoms. These data suggest that sex-related differences might exist in response to both medical and device therapies for patients with heart failure.
UR - http://www.scopus.com/inward/record.url?scp=84859101565&partnerID=8YFLogxK
U2 - 10.1038/nrcardio.2012.10
DO - 10.1038/nrcardio.2012.10
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C2 - 22330611
AN - SCOPUS:84859101565
SN - 1759-5002
VL - 9
SP - 234
EP - 242
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 4
ER -