Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease: A EUSTAR database analysis

Corrado Campochiaro; Anna Maria Hoffmann-Vold; Jerome Avouac; Jörg Henes; Jeska De Vries-Bouwstra; Vanessa Smith; Elise Siegert; Paolo Airò; Fahrettin Oksel; Raffaele Pellerito; Marie Vanthuyne; Maria Rosa Pozzi; Murat Inanc; Jean Sibilia; Armando Gabrielli; Oliver Distler; Yannick Allanore; Marco Matucci Cerinic; Ulrich Walker; Florenzo Iannone; Radim Becvar; Giovanna Cuomo; C. Montecucco; Patricia E. Carreira; Michele Iudici; Eugene J. Kucharz; Elisabetta Zanatta; Pr Dominique Farge Bancel; Roger Hesselstrand; Alexandra Balbir-Gurman; Raffaele Pellerito; Eugenia Bertoldo; Nemanja Damjanov; Vera Ortiz Santamaria Granollers; Stefan Heitmann; Maria João Salvador; Bojana Stamenkovic; Carlo Francesco Selmi; Ariane Herrick; Ulf Mü Ller-Ladner; Merete Engelhart; Valeria Riccieri; Ruxandra Maria Ionescu; Ana Maria Gheorghiu; Cord Sunderkötter; Jörg Distler; Francesca Ingegnoli; Luc Mouthon; Francesco Paolo Cantatore; Susanne Ullman; Piotr Wiland; Marie Vanthuyne; Petra Saar; Kristine Herrmann; Ellen De Langhe; Miroslav Mayer; Sule Yavuz; Carolina De Souza Müller; Thierry Zenone; Alessandra Vacca; Kamal Solanki; Edoardo Rosato; Fahrettin Oksel Figen Yargucu; Cristina Mihaela Tanaseanu; Rosario Foti; Daniel E. Furst; Peter Villiger Sabine Adler; Jorge Juan González Martín; Ira Litinsky; Francesco Del Galdo; Goda Seskute; Lesley Ann Saketkoo; Eduardo Kerzberg; Ivan Castellví; François Spertini; Vivien M. Hsu; Thierry Martin; Tim Schmeiser; Dominik Majewski; Vera Bernardino; Piercarlo Sarzi Puttini; Gianluca Moroncini; Jiri Stork; Eric Hachulla; Paloma Garcla De La Pena Lefebvre; Massimiliano Limonta; Petros Sfikakis; Maurizio Cutolo; Lidia P. Ananieva; Laszlo Czirjak; Christopher Denton; Giacomo De Luca; Lorenzo Dagna

doi:10.1093/rheumatology/keac660

Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease: A EUSTAR database analysis

Corrado Campochiaro, Anna Maria Hoffmann-Vold, Jerome Avouac, Jörg Henes, Jeska De Vries-Bouwstra, Vanessa Smith, Elise Siegert, Paolo Airò, Fahrettin Oksel, Raffaele Pellerito, Marie Vanthuyne, Maria Rosa Pozzi, Murat Inanc, Jean Sibilia, Armando Gabrielli, Oliver Distler, Yannick Allanore^*, Marco Matucci Cerinic, Ulrich Walker, Florenzo IannoneRadim Becvar, Giovanna Cuomo, C. Montecucco, Patricia E. Carreira, Michele Iudici, Eugene J. Kucharz, Elisabetta Zanatta, Pr Dominique Farge Bancel, Roger Hesselstrand, Alexandra Balbir-Gurman, Raffaele Pellerito, Eugenia Bertoldo, Nemanja Damjanov, Vera Ortiz Santamaria Granollers, Stefan Heitmann, Maria João Salvador, Bojana Stamenkovic, Carlo Francesco Selmi, Ariane Herrick, Ulf Mü Ller-Ladner, Merete Engelhart, Valeria Riccieri, Ruxandra Maria Ionescu, Ana Maria Gheorghiu, Cord Sunderkötter, Jörg Distler, Francesca Ingegnoli, Luc Mouthon, Francesco Paolo Cantatore, Susanne Ullman, Piotr Wiland, Marie Vanthuyne, Petra Saar, Kristine Herrmann, Ellen De Langhe, Miroslav Mayer, Sule Yavuz, Carolina De Souza Müller, Thierry Zenone, Alessandra Vacca, Kamal Solanki, Edoardo Rosato, Fahrettin Oksel Figen Yargucu, Cristina Mihaela Tanaseanu, Rosario Foti, Daniel E. Furst, Peter Villiger Sabine Adler, Jorge Juan González Martín, Ira Litinsky, Francesco Del Galdo, Goda Seskute, Lesley Ann Saketkoo, Eduardo Kerzberg, Ivan Castellví, François Spertini, Vivien M. Hsu, Thierry Martin, Tim Schmeiser, Dominik Majewski, Vera Bernardino, Piercarlo Sarzi Puttini, Gianluca Moroncini, Jiri Stork, Eric Hachulla, Paloma Garcla De La Pena Lefebvre, Massimiliano Limonta, Petros Sfikakis, Maurizio Cutolo, Lidia P. Ananieva, Laszlo Czirjak, Christopher Denton, Giacomo De Luca, Lorenzo Dagna

^*Corresponding author for this work

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Abstract

Objective: Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD. Methods: EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5-9%) and large progression (≥10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied. Results: A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)]. Conclusions: Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.

Original language	English
Pages (from-to)	2483-2491
Number of pages	9
Journal	Rheumatology
Volume	62
Issue number	7
DOIs	https://doi.org/10.1093/rheumatology/keac660
State	Published - 1 Jul 2023

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10.1093/rheumatology/keac660

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Campochiaro, C., Hoffmann-Vold, A. M., Avouac, J., Henes, J., De Vries-Bouwstra, J., Smith, V., Siegert, E., Airò, P., Oksel, F., Pellerito, R., Vanthuyne, M., Pozzi, M. R., Inanc, M., Sibilia, J., Gabrielli, A., Distler, O., Allanore, Y., Cerinic, M. M., Walker, U., ... Dagna, L. (2023). Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease: A EUSTAR database analysis. Rheumatology, 62(7), 2483-2491. https://doi.org/10.1093/rheumatology/keac660

@article{385fb44002ca47cfbb397580b51c8e3c,

title = "Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease: A EUSTAR database analysis",

abstract = "Objective: Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD. Methods: EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5-9%) and large progression (≥10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied. Results: A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)]. Conclusions: Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.",

author = "Corrado Campochiaro and Hoffmann-Vold, {Anna Maria} and Jerome Avouac and J{\"o}rg Henes and {De Vries-Bouwstra}, Jeska and Vanessa Smith and Elise Siegert and Paolo Air{\`o} and Fahrettin Oksel and Raffaele Pellerito and Marie Vanthuyne and Pozzi, {Maria Rosa} and Murat Inanc and Jean Sibilia and Armando Gabrielli and Oliver Distler and Yannick Allanore and Cerinic, {Marco Matucci} and Ulrich Walker and Florenzo Iannone and Radim Becvar and Giovanna Cuomo and C. Montecucco and Carreira, {Patricia E.} and Michele Iudici and Kucharz, {Eugene J.} and Elisabetta Zanatta and Bancel, {Pr Dominique Farge} and Roger Hesselstrand and Alexandra Balbir-Gurman and Raffaele Pellerito and Eugenia Bertoldo and Nemanja Damjanov and Granollers, {Vera Ortiz Santamaria} and Stefan Heitmann and Salvador, {Maria Jo{\~a}o} and Bojana Stamenkovic and Selmi, {Carlo Francesco} and Ariane Herrick and Ller-Ladner, {Ulf M{\"u}} and Merete Engelhart and Valeria Riccieri and Ionescu, {Ruxandra Maria} and Gheorghiu, {Ana Maria} and Cord Sunderk{\"o}tter and J{\"o}rg Distler and Francesca Ingegnoli and Luc Mouthon and Cantatore, {Francesco Paolo} and Susanne Ullman and Piotr Wiland and Marie Vanthuyne and Petra Saar and Kristine Herrmann and {De Langhe}, Ellen and Miroslav Mayer and Sule Yavuz and {De Souza M{\"u}ller}, Carolina and Thierry Zenone and Alessandra Vacca and Kamal Solanki and Edoardo Rosato and Yargucu, {Fahrettin Oksel Figen} and Tanaseanu, {Cristina Mihaela} and Rosario Foti and Furst, {Daniel E.} and Adler, {Peter Villiger Sabine} and Mart{\'i}n, {Jorge Juan Gonz{\'a}lez} and Ira Litinsky and {Del Galdo}, Francesco and Goda Seskute and Saketkoo, {Lesley Ann} and Eduardo Kerzberg and Ivan Castellv{\'i} and Fran{\c c}ois Spertini and Hsu, {Vivien M.} and Thierry Martin and Tim Schmeiser and Dominik Majewski and Vera Bernardino and Puttini, {Piercarlo Sarzi} and Gianluca Moroncini and Jiri Stork and Eric Hachulla and {De La Pena Lefebvre}, {Paloma Garcla} and Massimiliano Limonta and Petros Sfikakis and Maurizio Cutolo and Ananieva, {Lidia P.} and Laszlo Czirjak and Christopher Denton and {De Luca}, Giacomo and Lorenzo Dagna",

year = "2023",

month = jul,

day = "1",

doi = "10.1093/rheumatology/keac660",

language = "אנגלית",

volume = "62",

pages = "2483--2491",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "7",

}

Campochiaro, C, Hoffmann-Vold, AM, Avouac, J, Henes, J, De Vries-Bouwstra, J, Smith, V, Siegert, E, Airò, P, Oksel, F, Pellerito, R, Vanthuyne, M, Pozzi, MR, Inanc, M, Sibilia, J, Gabrielli, A, Distler, O, Allanore, Y, Cerinic, MM, Walker, U, Iannone, F, Becvar, R, Cuomo, G, Montecucco, C, Carreira, PE, Iudici, M, Kucharz, EJ, Zanatta, E, Bancel, PDF, Hesselstrand, R, Balbir-Gurman, A, Pellerito, R, Bertoldo, E, Damjanov, N, Granollers, VOS, Heitmann, S, Salvador, MJ, Stamenkovic, B, Selmi, CF, Herrick, A, Ller-Ladner, UM, Engelhart, M, Riccieri, V, Ionescu, RM, Gheorghiu, AM, Sunderkötter, C, Distler, J, Ingegnoli, F, Mouthon, L, Cantatore, FP, Ullman, S, Wiland, P, Vanthuyne, M, Saar, P, Herrmann, K, De Langhe, E, Mayer, M, Yavuz, S, De Souza Müller, C, Zenone, T, Vacca, A, Solanki, K, Rosato, E, Yargucu, FOF, Tanaseanu, CM, Foti, R, Furst, DE, Adler, PVS, Martín, JJG, Litinsky, I, Del Galdo, F, Seskute, G, Saketkoo, LA, Kerzberg, E, Castellví, I, Spertini, F, Hsu, VM, Martin, T, Schmeiser, T, Majewski, D, Bernardino, V, Puttini, PS, Moroncini, G, Stork, J, Hachulla, E, De La Pena Lefebvre, PG, Limonta, M, Sfikakis, P, Cutolo, M, Ananieva, LP, Czirjak, L, Denton, C, De Luca, G & Dagna, L 2023, 'Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease: A EUSTAR database analysis', Rheumatology, vol. 62, no. 7, pp. 2483-2491. https://doi.org/10.1093/rheumatology/keac660

TY - JOUR

T1 - Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease

T2 - A EUSTAR database analysis

AU - Campochiaro, Corrado

AU - Hoffmann-Vold, Anna Maria

AU - Avouac, Jerome

AU - Henes, Jörg

AU - De Vries-Bouwstra, Jeska

AU - Smith, Vanessa

AU - Siegert, Elise

AU - Airò, Paolo

AU - Oksel, Fahrettin

AU - Pellerito, Raffaele

AU - Vanthuyne, Marie

AU - Pozzi, Maria Rosa

AU - Inanc, Murat

AU - Sibilia, Jean

AU - Gabrielli, Armando

AU - Distler, Oliver

AU - Allanore, Yannick

AU - Cerinic, Marco Matucci

AU - Walker, Ulrich

AU - Iannone, Florenzo

AU - Becvar, Radim

AU - Cuomo, Giovanna

AU - Montecucco, C.

AU - Carreira, Patricia E.

AU - Iudici, Michele

AU - Kucharz, Eugene J.

AU - Zanatta, Elisabetta

AU - Bancel, Pr Dominique Farge

AU - Hesselstrand, Roger

AU - Balbir-Gurman, Alexandra

AU - Pellerito, Raffaele

AU - Bertoldo, Eugenia

AU - Damjanov, Nemanja

AU - Granollers, Vera Ortiz Santamaria

AU - Heitmann, Stefan

AU - Salvador, Maria João

AU - Stamenkovic, Bojana

AU - Selmi, Carlo Francesco

AU - Herrick, Ariane

AU - Ller-Ladner, Ulf Mü

AU - Engelhart, Merete

AU - Riccieri, Valeria

AU - Ionescu, Ruxandra Maria

AU - Gheorghiu, Ana Maria

AU - Sunderkötter, Cord

AU - Distler, Jörg

AU - Ingegnoli, Francesca

AU - Mouthon, Luc

AU - Cantatore, Francesco Paolo

AU - Ullman, Susanne

AU - Wiland, Piotr

AU - Vanthuyne, Marie

AU - Saar, Petra

AU - Herrmann, Kristine

AU - De Langhe, Ellen

AU - Mayer, Miroslav

AU - Yavuz, Sule

AU - De Souza Müller, Carolina

AU - Zenone, Thierry

AU - Vacca, Alessandra

AU - Solanki, Kamal

AU - Rosato, Edoardo

AU - Yargucu, Fahrettin Oksel Figen

AU - Tanaseanu, Cristina Mihaela

AU - Foti, Rosario

AU - Furst, Daniel E.

AU - Adler, Peter Villiger Sabine

AU - Martín, Jorge Juan González

AU - Litinsky, Ira

AU - Del Galdo, Francesco

AU - Seskute, Goda

AU - Saketkoo, Lesley Ann

AU - Kerzberg, Eduardo

AU - Castellví, Ivan

AU - Spertini, François

AU - Hsu, Vivien M.

AU - Martin, Thierry

AU - Schmeiser, Tim

AU - Majewski, Dominik

AU - Bernardino, Vera

AU - Puttini, Piercarlo Sarzi

AU - Moroncini, Gianluca

AU - Stork, Jiri

AU - Hachulla, Eric

AU - De La Pena Lefebvre, Paloma Garcla

AU - Limonta, Massimiliano

AU - Sfikakis, Petros

AU - Cutolo, Maurizio

AU - Ananieva, Lidia P.

AU - Czirjak, Laszlo

AU - Denton, Christopher

AU - De Luca, Giacomo

AU - Dagna, Lorenzo

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Objective: Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD. Methods: EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5-9%) and large progression (≥10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied. Results: A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)]. Conclusions: Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.

AB - Objective: Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD. Methods: EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5-9%) and large progression (≥10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied. Results: A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)]. Conclusions: Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.

UR - http://www.scopus.com/inward/record.url?scp=85164246115&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/keac660

DO - 10.1093/rheumatology/keac660

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 36413079

AN - SCOPUS:85164246115

SN - 1462-0324

VL - 62

SP - 2483

EP - 2491

JO - Rheumatology

JF - Rheumatology

IS - 7

ER -

Sex influence on outcomes of patients with systemic sclerosis-associated interstitial lung disease: A EUSTAR database analysis

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