Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues

David R. Crawford; Sanju Sinha; Nishanth Ulhas Nair; Bríd M. Ryan; Jill S. Barnholtz-Sloan; Stephen M. Mount; Ayelet Erez; Kenneth Aldape; Philip E. Castle; Padma S. Rajagopal; Chi Ping Day; Alejandro A. Schäffer; Eytan Ruppin

doi:10.3390/cancers14235885

Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues

David R. Crawford, Sanju Sinha, Nishanth Ulhas Nair, Bríd M. Ryan, Jill S. Barnholtz-Sloan, Stephen M. Mount, Ayelet Erez, Kenneth Aldape, Philip E. Castle, Padma S. Rajagopal, Chi Ping Day, Alejandro A. Schäffer, Eytan Ruppin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Cancer occurs more frequently in men while autoimmune diseases (AIDs) occur more frequently in women. To explore whether these sex biases have a common basis, we collected 167 AID incidence studies from many countries for tissues that have both a cancer type and an AID that arise from that tissue. Analyzing a total of 182 country-specific, tissue-matched cancer-AID incidence rate sex bias data pairs, we find that, indeed, the sex biases observed in the incidence of AIDs and cancers that occur in the same tissue are positively correlated across human tissues. The common key factor whose levels across human tissues are most strongly associated with these incidence rate sex biases is the sex bias in the expression of the 37 genes encoded in the mitochondrial genome.

Original language	English
Article number	5885
Journal	Cancers
Volume	14
Issue number	23
DOIs	https://doi.org/10.3390/cancers14235885
State	Published - Dec 2022
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health
National Cancer Institute

Keywords

autoimmune disease incidence
autoimmunity
cancer incidence
immunity
inflammation
mitochondria
sex bias

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers14235885

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Crawford, D. R., Sinha, S., Nair, N. U., Ryan, B. M., Barnholtz-Sloan, J. S., Mount, S. M., Erez, A., Aldape, K., Castle, P. E., Rajagopal, P. S., Day, C. P., Schäffer, A. A., & Ruppin, E. (2022). Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues. Cancers, 14(23), Article 5885. https://doi.org/10.3390/cancers14235885

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title = "Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues",

abstract = "Cancer occurs more frequently in men while autoimmune diseases (AIDs) occur more frequently in women. To explore whether these sex biases have a common basis, we collected 167 AID incidence studies from many countries for tissues that have both a cancer type and an AID that arise from that tissue. Analyzing a total of 182 country-specific, tissue-matched cancer-AID incidence rate sex bias data pairs, we find that, indeed, the sex biases observed in the incidence of AIDs and cancers that occur in the same tissue are positively correlated across human tissues. The common key factor whose levels across human tissues are most strongly associated with these incidence rate sex biases is the sex bias in the expression of the 37 genes encoded in the mitochondrial genome.",

keywords = "autoimmune disease incidence, autoimmunity, cancer incidence, immunity, inflammation, mitochondria, sex bias",

author = "Crawford, {David R.} and Sanju Sinha and Nair, {Nishanth Ulhas} and Ryan, {Br{\'i}d M.} and Barnholtz-Sloan, {Jill S.} and Mount, {Stephen M.} and Ayelet Erez and Kenneth Aldape and Castle, {Philip E.} and Rajagopal, {Padma S.} and Day, {Chi Ping} and Sch{\"a}ffer, {Alejandro A.} and Eytan Ruppin",

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year = "2022",

month = dec,

doi = "10.3390/cancers14235885",

language = "אנגלית",

volume = "14",

journal = "Cancers",

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Crawford, DR, Sinha, S, Nair, NU, Ryan, BM, Barnholtz-Sloan, JS, Mount, SM, Erez, A, Aldape, K, Castle, PE, Rajagopal, PS, Day, CP, Schäffer, AA & Ruppin, E 2022, 'Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues', Cancers, vol. 14, no. 23, 5885. https://doi.org/10.3390/cancers14235885

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AU - Crawford, David R.

AU - Sinha, Sanju

AU - Nair, Nishanth Ulhas

AU - Ryan, Bríd M.

AU - Barnholtz-Sloan, Jill S.

AU - Mount, Stephen M.

AU - Erez, Ayelet

AU - Aldape, Kenneth

AU - Castle, Philip E.

AU - Rajagopal, Padma S.

AU - Day, Chi Ping

AU - Schäffer, Alejandro A.

AU - Ruppin, Eytan

PY - 2022/12

Y1 - 2022/12

N2 - Cancer occurs more frequently in men while autoimmune diseases (AIDs) occur more frequently in women. To explore whether these sex biases have a common basis, we collected 167 AID incidence studies from many countries for tissues that have both a cancer type and an AID that arise from that tissue. Analyzing a total of 182 country-specific, tissue-matched cancer-AID incidence rate sex bias data pairs, we find that, indeed, the sex biases observed in the incidence of AIDs and cancers that occur in the same tissue are positively correlated across human tissues. The common key factor whose levels across human tissues are most strongly associated with these incidence rate sex biases is the sex bias in the expression of the 37 genes encoded in the mitochondrial genome.

AB - Cancer occurs more frequently in men while autoimmune diseases (AIDs) occur more frequently in women. To explore whether these sex biases have a common basis, we collected 167 AID incidence studies from many countries for tissues that have both a cancer type and an AID that arise from that tissue. Analyzing a total of 182 country-specific, tissue-matched cancer-AID incidence rate sex bias data pairs, we find that, indeed, the sex biases observed in the incidence of AIDs and cancers that occur in the same tissue are positively correlated across human tissues. The common key factor whose levels across human tissues are most strongly associated with these incidence rate sex biases is the sex bias in the expression of the 37 genes encoded in the mitochondrial genome.

KW - autoimmune disease incidence

KW - autoimmunity

KW - cancer incidence

KW - immunity

KW - inflammation

KW - mitochondria

KW - sex bias

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Sex Biases in Cancer and Autoimmune Disease Incidence Are Strongly Positively Correlated with Mitochondrial Gene Expression across Human Tissues

Abstract

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Keywords

UN SDGs

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