Severe tumor lysis syndrome following splenic irradiation

Theodor Schifter*, Amos Cohen, Uri H. Lewinski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A 72-year-old man suffering from non-Hodgkin's lymphoma is described. After failing to respond to chlorambucil-prednisone regimen for three months, he was treated by splenic irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs following chemotherapy, can also be radiation-induced.

Original languageEnglish
Pages (from-to)75-76
Number of pages2
JournalAmerican Journal of Hematology
Issue number1
StatePublished - 1999


  • Acute renal failure
  • Radiation therapy
  • Splenic irradiation
  • Tumor lysis syndrome


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