TY - JOUR
T1 - Severe tumor lysis syndrome following splenic irradiation
AU - Schifter, Theodor
AU - Cohen, Amos
AU - Lewinski, Uri H.
PY - 1999
Y1 - 1999
N2 - A 72-year-old man suffering from non-Hodgkin's lymphoma is described. After failing to respond to chlorambucil-prednisone regimen for three months, he was treated by splenic irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs following chemotherapy, can also be radiation-induced.
AB - A 72-year-old man suffering from non-Hodgkin's lymphoma is described. After failing to respond to chlorambucil-prednisone regimen for three months, he was treated by splenic irradiation (total dose 500 cGY) in 10 consecutive daily doses. Two days after the last irradiation, the patient developed acute tumor lysis syndrome (TLS) with extreme blood levels of uric acid (33.7 mg/dl), phosphorus (13.7 mg/dl), potassium (6.08 mEq/l), and calcium (6.8 mg/dl). It should be remembered that the acute TLS, which usually occurs following chemotherapy, can also be radiation-induced.
KW - Acute renal failure
KW - Radiation therapy
KW - Splenic irradiation
KW - Tumor lysis syndrome
UR - http://www.scopus.com/inward/record.url?scp=0032889519&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1096-8652(199901)60:1<75::AID-AJH14>3.0.CO;2-2
DO - 10.1002/(SICI)1096-8652(199901)60:1<75::AID-AJH14>3.0.CO;2-2
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AN - SCOPUS:0032889519
SN - 0361-8609
VL - 60
SP - 75
EP - 76
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 1
ER -