Severe pseudohypoaldosteronism in a pair of twins not associated with hydramnios

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Abstract

A pair of non-identical twins with severe pseudohypoaldosteronism (PHA) were followed over a period of 4 years. The diagnosis was based on dehydration, hyponatremia, hyperkalemia, high urine sodium/potassium ratios, and high serum concentrations of aldosterone and renin. Sweat and saliva electrolyte concentrations were high, suggesting multifocal target-organ unresponsiveness to mineralocorticoids. No hydramnios was observed during pregnancy. Despite continuous treatment with sodium chloride and sodium bicarbonate (≤ 20 g/day) and cation exchange resin (Kayexalate, sodium polystyrene sulfonate, ≤ 4 g/kg per day), the children had repeated episodes of dehydration, hyponatremia, and hyperkalemia. Growth velocity was normal in both twins. Catch-up growth was observed following infancy in the first twin. Normalization of plasma aldosterone, electrolytes, and renin concentrations was achieved at the age of 9 months.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalPediatric Nephrology
Volume10
Issue number4
DOIs
StatePublished - 1996

Keywords

  • Hydramnios
  • Pseudohypoaldosteronism
  • Twins

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