Severe pregnancy complications are associated with elevated factor VIII plasma activity

Eli Rimon, Jessica Ascher-Landsberg, Noga Carmi, Ariel Many, Varda Deutsch, Michael J. Kupferminc

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study is to investigate the prevalence of elevated factor VIII activity among women with severe complications of pregnancy. The study group included 49 patients with a previous history of pregnancy complications: severe preeclampsia (n = 9); intrauterine fetal death (IUFD) (n = 9); severe intrauterine fetal growth restriction (IUGR) (n = 12); IUGR and preeclampsia (n = 7); preeclampsia and placental abruption (n = 2); IUFD and IUGR (n = 5); and abruptio placenta (n = 5). The control group included 49 healthy women who had had at least one normal pregnancy. Seventeen women of the study group (34.6%) had elevated factor VIII activity compared to one woman (2.1%) in the control group (P < 0.05). The mean level of factor VIII was 159 ± 52% and 88 ± 17.4% of normal activity (mean ± SD, t-test, P < 0.05). Importantly, 10 women of the study group (20.4%) had only elevated factor VIII activity with no other known thrombophilia compared to one woman (2.1%) in the control group (P < 0.05). Elevated plasma activity of factor VIII might be a risk factor for severe pregnancy complications.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Volume23
Issue number3
DOIs
StatePublished - Apr 2012

Keywords

  • factor VIII
  • severe pregnancy complications
  • thrombophilia

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