Severe migratory polyarthritis following in vivo CAMPATH-1G

G. Varadi, R. Or, D. Rund, H. Orbach, S. Slavin, A. Nagler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

CAMPATH-1G is an IgG2b rat antihuman (CDw52) monoclonal antibody (MoAb) which is currently being used for T cell depletion in the setting of allogeneic bone marrow transplantation (BMT). In addition it elicits substantial lymphoid depletion, an effect which is being explored for remission induction in patients with lymphoid malignancies and for treating patients with various autoimmune disorders, in particular rheumatoid arthritis. Recently, in vivo CAMPATH-1G has been introduced to achieve increased immunosuppression in the pretransplant conditioning, for prevention of graft rejection following T cell depleted BMT. Here we describe a patient with T cell lymphoblastic lymphoma who received in vivo CAMPATH-1G as part of the pretransplant conditioning regimen and who, 6 days after the first dose, developed severe migratory polyarthritis. This is the first report of severe migratory polyarthritis as a very unusual complication following CAMPATH-1G MoAb administration.

Original languageEnglish
Pages (from-to)843-845
Number of pages3
JournalBone Marrow Transplantation
Volume16
Issue number6
StatePublished - 1995
Externally publishedYes

Keywords

  • CAMPATH-1G
  • Polyarthritis
  • Serum sickness

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