Severe defect in clearing postprandial chylomicron remnants in dialysis patients

Moshe Weintraub, Amira Burstein, Toby Rassin, Meir Liron, Yehuda Ringel, Shaltiel Cabili, Miriam Blum, Gary Peer, Adrian Iaina

Research output: Contribution to journalArticlepeer-review

Abstract

Lipid abnormalities have been suggested as a major cause of the accelerated atherosclerosis and the high incidence of coronary heart disease in chronic renal failure patients. In the present work the postprandial lipoprotein metabolism was studied in chronic dialysis patients with or without fasting hypertriglyceridemia using the vitamin A loading test. This method investigates specifically postprandial lipoprotein metabolism. The determination of vitamin A ester level retinyl palmitate (RP) differentiates the circulating plasma chylomicron and chylomicron remnant fractions from the endogenous VLDL and IDL. Subjects with normal renal function with or without fasting hypertriglyceridemia served as control groups. Dialysis patients have significantly higher level of chylomicron remnants for a more prolonged period of time than controls, irrespective of their fasting triglyceride levels. The area below retinyl palmitate chylomicron remnants curve was 26308 ± 12422 μg/liter · hr in the normolipidemic dialysis patients, significantly higher than (6393 ± 2098 μg/liter · hr; P < 0.0001) in the normolipidemic controls. The retinyl palmitate chylomicron remnants curve of the hypertriglyceridemic dialysis patients was 21021 ± 4560 μg/liter · hr, which was higher than 12969 ± 2215 μg/liter · hr (P < 0.0001) in the hypertriglyceridemic controls. Moreover, the hypertriglyceridemic dialysis patients had an additional defect in the lipolysis metabolic step, that is, accumulation of chylomicrons in circulation. These findings show a severe defect in postprandial lipoprotein metabolism in chronic renal failure patients. The prolonged exposure of the vascular wall to high chylomicron remnant concentrations might be an important pathogenetic factor in the accelerated atherosclerosis seen in chronic dialysis patients.

Original languageEnglish
Pages (from-to)1247-1252
Number of pages6
JournalKidney International
Volume42
Issue number5
DOIs
StatePublished - Nov 1992
Externally publishedYes

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