Severe Clostridium difficile-associated colitis in young patients with cystic fibrosis

J. Rivlin, A. Lerner, A. Augarten, M. Wilschanski, E. Kerem, M. A. Ephros

Research output: Contribution to journalArticlepeer-review

Abstract

We report four patients with cystic fibrosis and fulminant Clostridium difficile-associated colitis: two died, and one required hemicolectomy. Three of four patients carried the N1303K mutation. Severe and fatal C. difficile colitis can occur in cystic fibrosis patients, possibly with a genotype- specific predilection (i.e., N1303K/other). Because cystic fibrosis patients may have a wide spectrum of gastrointestinal symptoms, disease caused by C. difficile must be considered when these patients have acute abdominal pain, diarrhea, or severe leukocytosis.

Original languageEnglish
Pages (from-to)177-179
Number of pages3
JournalJournal of Pediatrics
Volume132
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

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