TY - JOUR
T1 - Severe Clostridium difficile-associated colitis in young patients with cystic fibrosis
AU - Rivlin, J.
AU - Lerner, A.
AU - Augarten, A.
AU - Wilschanski, M.
AU - Kerem, E.
AU - Ephros, M. A.
PY - 1998
Y1 - 1998
N2 - We report four patients with cystic fibrosis and fulminant Clostridium difficile-associated colitis: two died, and one required hemicolectomy. Three of four patients carried the N1303K mutation. Severe and fatal C. difficile colitis can occur in cystic fibrosis patients, possibly with a genotype- specific predilection (i.e., N1303K/other). Because cystic fibrosis patients may have a wide spectrum of gastrointestinal symptoms, disease caused by C. difficile must be considered when these patients have acute abdominal pain, diarrhea, or severe leukocytosis.
AB - We report four patients with cystic fibrosis and fulminant Clostridium difficile-associated colitis: two died, and one required hemicolectomy. Three of four patients carried the N1303K mutation. Severe and fatal C. difficile colitis can occur in cystic fibrosis patients, possibly with a genotype- specific predilection (i.e., N1303K/other). Because cystic fibrosis patients may have a wide spectrum of gastrointestinal symptoms, disease caused by C. difficile must be considered when these patients have acute abdominal pain, diarrhea, or severe leukocytosis.
UR - http://www.scopus.com/inward/record.url?scp=0031893534&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(98)70511-6
DO - 10.1016/S0022-3476(98)70511-6
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AN - SCOPUS:0031893534
VL - 132
SP - 177
EP - 179
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1
ER -
