Severe and morbid obesity in Crohn's disease patients: Prevalence and disease associations

Bella Ungar, Uri Kopylov, David Goitein, Adi Lahat, Eitan Bardan, Benjamin Avidan, Alon Lang, Yaakov Maor, Rami Eliakim, Shomron Ben-Horin

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Crohn's disease (CD) is frequently associated with weight loss and malnutrition. However, as the prevalence of obesity increases worldwide, it may become a clinical problem even in CD. Aim: To assess the prevalence of severe/morbid obesity in CD patients and to compare their disease characteristics to nonobese CD patients. Methods: A retrospective analysis of a computerized CD patient database was performed to identify severely/morbidly obese patients (BMI >35). Prevalence was compared to data of the general population. Severely/morbidly obese CD patients were then compared to randomly selected nonobese CD patients (BMI <30) in a 1:3 ratio. Results: Thirteen severely/morbidly obese patients out of 560 CD patients were found (2.3%), which is significantly lower than the prevalence in the general population (5.6%, p = 0.001). When compared to 39 nonobese CD patients, colonic disease was significantly more common among severely/morbidly obese CD patients (odds ratio: 6, 95% CI: 1.35-26.3, p = 0.02), while there was no difference in other disease parameters. Interestingly, 4 morbidly obese CD patients had undergone laparoscopic sleeve gastrectomy for treatment of morbid obesity with a favorable surgical course. Conclusion: CD in severely/morbidly obese patients is more often colonic, but otherwise no different than CD in nonobese patients. Sleeve gastrectomy is a viable therapeutic option for morbidly obese CD patients.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalDigestion
Volume88
Issue number1
DOIs
StatePublished - Jul 2013

Keywords

  • Crohn's disease
  • Morbid obesity
  • Severe obesity

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