Serum transforming growth factor beta-1 post hip fracture repair in elderly patients

Yichayaou Beloosesky, Avraham Weiss, Avital Hershkovitz, David Hendel, Vivian Barak

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To determine the kinetics of serum transforming growth factor beta-1 (TGF-β1) in aged hip fracture patients during a month post-op. and determine its relationship to complications and cognitive status. Methods: Forty-one elderly patients were prospectively followed. Serum TGF-β1 was obtained during the first 10 h post-fracture (baseline) and pre-surgery, 48-60 h post-op., 7 and 30 days post-op. Results: Mean age was 81.8 ± 7.7, range 68-97 years. A significant increase in serum TGF-β1 (from baseline) was observed on the seventh day post-op., lasting for at least 1 month (p= 0.004). Sixteen patients experienced post-op. complications. Serum TGF-β1 of patients with complications was significantly higher compared to patients without complications (p= 0.039). More complications were found in impaired mental status (IMS) patients (9/12) compared to cognitively normal patients (10/29), (p= 0.037). However, no differences were found in serum TGF-β1 between IMS and normal patients, nor was a correlation found between age and TGF-β1 production. No differences were found between genders. Conclusions: There is a distinct increase in serum TGF-β1, a week post hip fracture repair, lasting for at least a month, which is significantly higher in patients with post-op. complications. TGF-β1 seems to be essential to the healing process post hip fracture repair; still its clinical applications have as yet to be determined.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalCytokine
Volume54
Issue number1
DOIs
StatePublished - Apr 2011

Keywords

  • Elderly
  • Hip-fracture
  • Surgery
  • TGF-β1

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