Serum-sickness-like reaction associated with minocycline therapy in adolescents

Liora Harel; Jacob Amir; Ella Livni; Rachel Straussberg; Itzhak Varsano

doi:10.1177/106002809603000509

Serum-sickness-like reaction associated with minocycline therapy in adolescents

Liora Harel, Jacob Amir, Ella Livni, Rachel Straussberg, Itzhak Varsano

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To describe a serum-sickness-like reaction in five adolescents treated with minocycline. CASE SUMMARY: Five adolescents developed a rash and arthralgias/arthritis after taking minocycline for 10-30 days. Symptoms resolved gradually after the medication was stopped. DISCUSSION: Serum sickness is not described in the pharmacology literature as an adverse effect of minocycline, and in the English literature there are only two case reports. The migration inhibitory factor assay and most cell degranulation test were positive in four of the five patients. The results of these assays were consistent with a role for minocycline in causing these reactions. CONCLUSIONS: Clinicians should be aware of the possibility of serum-sickness- like reaction as an adverse effect of minocycline.

Original language	English
Pages (from-to)	481-483
Number of pages	3
Journal	Annals of Pharmacotherapy
Volume	30
Issue number	5
DOIs	https://doi.org/10.1177/106002809603000509
State	Published - 1996
Externally published	Yes

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title = "Serum-sickness-like reaction associated with minocycline therapy in adolescents",

abstract = "OBJECTIVE: To describe a serum-sickness-like reaction in five adolescents treated with minocycline. CASE SUMMARY: Five adolescents developed a rash and arthralgias/arthritis after taking minocycline for 10-30 days. Symptoms resolved gradually after the medication was stopped. DISCUSSION: Serum sickness is not described in the pharmacology literature as an adverse effect of minocycline, and in the English literature there are only two case reports. The migration inhibitory factor assay and most cell degranulation test were positive in four of the five patients. The results of these assays were consistent with a role for minocycline in causing these reactions. CONCLUSIONS: Clinicians should be aware of the possibility of serum-sickness- like reaction as an adverse effect of minocycline.",

author = "Liora Harel and Jacob Amir and Ella Livni and Rachel Straussberg and Itzhak Varsano",

year = "1996",

doi = "10.1177/106002809603000509",

language = "אנגלית",

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T1 - Serum-sickness-like reaction associated with minocycline therapy in adolescents

AU - Harel, Liora

AU - Amir, Jacob

AU - Livni, Ella

AU - Straussberg, Rachel

AU - Varsano, Itzhak

PY - 1996

Y1 - 1996

N2 - OBJECTIVE: To describe a serum-sickness-like reaction in five adolescents treated with minocycline. CASE SUMMARY: Five adolescents developed a rash and arthralgias/arthritis after taking minocycline for 10-30 days. Symptoms resolved gradually after the medication was stopped. DISCUSSION: Serum sickness is not described in the pharmacology literature as an adverse effect of minocycline, and in the English literature there are only two case reports. The migration inhibitory factor assay and most cell degranulation test were positive in four of the five patients. The results of these assays were consistent with a role for minocycline in causing these reactions. CONCLUSIONS: Clinicians should be aware of the possibility of serum-sickness- like reaction as an adverse effect of minocycline.

AB - OBJECTIVE: To describe a serum-sickness-like reaction in five adolescents treated with minocycline. CASE SUMMARY: Five adolescents developed a rash and arthralgias/arthritis after taking minocycline for 10-30 days. Symptoms resolved gradually after the medication was stopped. DISCUSSION: Serum sickness is not described in the pharmacology literature as an adverse effect of minocycline, and in the English literature there are only two case reports. The migration inhibitory factor assay and most cell degranulation test were positive in four of the five patients. The results of these assays were consistent with a role for minocycline in causing these reactions. CONCLUSIONS: Clinicians should be aware of the possibility of serum-sickness- like reaction as an adverse effect of minocycline.

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Serum-sickness-like reaction associated with minocycline therapy in adolescents

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