Serum proteins as mediators of hemin efflux from red cell membranes: specificity of hemopexin

I. Solar, U. Muller-Eberhard, N. Shaklai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The involvement of the serum heme-binding proteins hemopexin and albumin in the clearance of erythrocyte membranes from toxic hemin was compared. In the presence of hemopexin initial rates of hemin efflux from resealed ghosts were faster and the amount of extracted hemin larger. When hemin-containing ghosts were treated with a protein mixture of 1:45 hemopexin to albumin, as present in serum, most of the hemin was extracted in the form of heme-hemopexin. It was concluded that hemopexin is the serum protein responsible for heme extraction from cell membranes. Hemin; Hemopexin; Albumin; Erythrocyte membrane.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalFEBS Letters
Volume256
Issue number1-2
DOIs
StatePublished - 9 Oct 1989

Funding

FundersFunder number
National Institute of Diabetes and Digestive and Kidney DiseasesR01DK030203
National Institute of Diabetes and Digestive and Kidney Diseases

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