Serum progesterone concentration on the day of embryo transfer in stimulated cycles does not correlate with reproductive outcomes

Genia Rozen*, Peter Rogers, Yossi Mizrachi, Wan Tinn Teh, Chandrika Parmar, Alex Polyakov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Research question: Is the live birth rate (LBR) in fresh embryo transfer IVF cycles affected by serum progesterone concentration on the day of embryo transfer? Design: A single-centre retrospective analysis of prospectively collected data from women who underwent IVF or intracytoplasmic sperm injection between July 2019 and July 2020, and had a fresh day 5 single embryo transfer. Overall, 825 first and second stimulation cycles were included. Patients underwent a gonadotrophin-releasing hormone antagonist protocol with human chorionic gonadotrophin (HCG) trigger, and received vaginal-only luteal phase support. The study population was an everyday patient cohort, treated with the unit's usual stimulation protocols. The correlation between serum progesterone concentrations on the day of embryo transfer and the incidence of positive HCG, clinical pregnancy and live birth were examined. Patients were divided into four groups based on serum progesterone concentrations (<150, 150–250, 251–400 and >400 nmol/l). The data were further interrogated using additional progesterone cut-offs. Results: There was no concentration of progesterone below or above which the chance of pregnancy was reduced. The chance of live birth following a blastocyst transfer was no different across the four groups (29.8, 26.6, 32.7 and 31.5%, respectively, P = 0.55). There was no negative association between progesterone and chance of pregnancy when other progesterone thresholds were applied. Estimates were adjusted for confounding factors such as maternal age. Conclusion: Serum progesterone concentration on the day of fresh embryo transfer does not correlate with the LBR.

Original languageEnglish
Pages (from-to)1160-1166
Number of pages7
JournalReproductive BioMedicine Online
Volume45
Issue number6
DOIs
StatePublished - Dec 2022

Keywords

  • Blastocyst
  • Embryo transfer
  • Fertility
  • IVF
  • Luteal phase
  • Progesterone
  • Reproduction

Fingerprint

Dive into the research topics of 'Serum progesterone concentration on the day of embryo transfer in stimulated cycles does not correlate with reproductive outcomes'. Together they form a unique fingerprint.

Cite this